Rani Indu, Kumar Rakesh, Singha Harisankar, Riyesh Thachamvalley, Vaid Rajesh Kumar, Bhattacharya Tarun Kumar, Shanmugasundaram Karuppusamy
ICAR-National Research Centre on Equines, Hisar, Haryana, India.
Department of Microbiology, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana, India.
Front Public Health. 2025 Mar 21;13:1505967. doi: 10.3389/fpubh.2025.1505967. eCollection 2025.
Globally, the incidence and burden of zoonotic tuberculosis (zTB) in humans are underestimated. Earlier, it was considered that () was the sole etiology of zTB; however, novel zoonotic species of mycobacteria, namely, (), is also implicated and often neglected pathogen, which necessitates more attention. has been recently included under the members of the complex (MTBC), and it shares genetic similarities with other members of this complex. can cause tuberculosis (TB) in animals and humans. This bacterium is harbored by a wide range of host species; however, the exact host spectrum is not well understood. In recent years, has received considerable interest due to its frequent isolation in zTB infections that often originated from tuberculosis-endemic countries than non-endemic countries. Therefore, the zoonotic potential of this bacterium highlights the importance of "One Health" approaches in understanding its possible routes of transmission, reservoir, ecology, and pathogenicity. Moreover, the occurrence of in tuberculosis-endemic countries with limited resources poses further challenges in disease surveillance and identification, emphasizing the significance of collaborative measures across multiple sectors to monitor and control its spread. This review focuses on the current knowledge of and underscores the importance of this neglected pathogen, which has potential impacts on both human and animal health.
在全球范围内，人兽共患结核病（zTB）在人类中的发病率和负担被低估了。早些时候，人们认为（）是人兽共患结核病的唯一病因；然而，新型分枝杆菌人畜共患病原体，即（），也是一种常被忽视的病原体，这需要更多关注。（）最近已被纳入结核分枝杆菌复合群（MTBC）成员，并且与该复合群的其他成员具有遗传相似性。（）可导致动物和人类患结核病。这种细菌存在于多种宿主物种中；然而，确切的宿主范围尚不清楚。近年来，由于（）在人兽共患结核病感染中频繁分离出来，且这些感染往往起源于结核病流行国家而非非流行国家，因此受到了相当大的关注。因此，这种细菌的人畜共患病潜力凸显了“同一健康”方法在了解其可能的传播途径、宿主、生态学和致病性方面的重要性。此外，在资源有限的结核病流行国家中（）的出现给疾病监测和识别带来了进一步挑战，强调了跨多个部门采取协作措施来监测和控制其传播的重要性。本综述重点关注（）的现有知识，并强调这种被忽视的病原体的重要性，它对人类和动物健康都有潜在影响。
