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美国国立卫生研究院脑肿瘤研究资金分配的当前趋势。

Current trends in the allocation of National Institute of Health funding of brain tumor research.

作者信息

Nawabi Noah L A, Saway Brian F, Jha Rohan, Pereira Matheus, Mehta Neel H, Das Arabinda, Zukas Alicia, Lindhorst Scott, Strickland Ben A

机构信息

College of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina.

出版信息

Neurooncol Adv. 2024 Dec 4;7(1):vdae203. doi: 10.1093/noajnl/vdae203. eCollection 2025 Jan-Dec.


DOI:10.1093/noajnl/vdae203
PMID:40191402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11969036/
Abstract

BACKGROUND: The National Institute of Health (NIH) provides a sizable annual budget toward brain tumor research. However, funding allocation for specific pathologies remains poorly described. We aimed to characterize the current landscape of NIH funding toward brain tumors as a function of pathology. METHODS: NIHRePORTER was queried to identify studies focused on glioblastoma, pediatric glioma, oligodendroglioma, brain metastasis, meningioma, pituitary adenoma, and vestibular schwannoma, from 2000 to 2023. Studies with R, U, and P funding mechanisms were included. Data were compiled and assessed according to pathology. RESULTS: Across these 7 tumors, 3320 unique studies with R, U, or P funding mechanisms were identified from 2000 to 2023. These were conducted across 480 unique institutions. The sum of funds allocated to all studies was $1 607 662 631. Glioblastoma commanded the largest portion of funds, representing 54% of R mechanisms, 55% of R01-funded studies, 48% of U mechanisms, and 49% of P mechanisms, and accounted for 51% ($813 556 423) of total funding. Brain metastasis was the second most-funded tumor, representing 31% of all R mechanisms, 31% of all R01-funded studies, 26% of all U mechanisms, and 28% of all P mechanisms, and accounted for 29% ($472 715 745) of funding. The remaining 14% of R mechanisms, 26% of U mechanisms, and 23% of P mechanisms focused on the remaining pathologies, and accounted for 20% ($321 390 463) of funding. CONCLUSIONS: The current landscape of NIH funding for brain tumor research indicates that awarded mechanisms prioritize malignant intra-axial malignancies. Despite their prevalence, skull base neoplasia is far less represented in NIH-funded studies.

摘要

背景:美国国立卫生研究院(NIH)每年为脑肿瘤研究提供大量预算。然而,针对特定病理类型的资金分配情况仍描述不清。我们旨在描述NIH当前针对脑肿瘤的资金分配格局与病理类型之间的关系。 方法:通过查询NIHRePORTER,确定2000年至2023年期间专注于胶质母细胞瘤、小儿胶质瘤、少突胶质细胞瘤、脑转移瘤、脑膜瘤、垂体腺瘤和前庭神经鞘瘤的研究。纳入具有R、U和P资助机制的研究。根据病理类型对数据进行汇总和评估。 结果:在这7种肿瘤中,2000年至2023年期间共确定了3320项具有R、U或P资助机制的独特研究。这些研究在480个不同的机构开展。分配给所有研究的资金总额为1607662631美元。胶质母细胞瘤获得的资金份额最大,占R机制的54%、R01资助研究的55%、U机制的48%和P机制的49%,占总资金的51%(813556423美元)。脑转移瘤是获得资金第二多的肿瘤,占所有R机制的31%、所有R01资助研究的31%、所有U机制的26%和所有P机制的28%,占资金的29%(472715745美元)。其余14%的R机制、26%的U机制和23%的P机制专注于其余病理类型,占资金的20%(321390463美元)。 结论:NIH目前用于脑肿瘤研究的资金分配格局表明,资助机制优先考虑恶性轴内恶性肿瘤。尽管颅底肿瘤很常见,但在NIH资助的研究中所占比例却小得多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/fdd983078a2b/vdae203_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/bbdaec571810/vdae203_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/4d961d870bd2/vdae203_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/0376aa7ff0da/vdae203_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/fdd983078a2b/vdae203_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/bbdaec571810/vdae203_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/4d961d870bd2/vdae203_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/0376aa7ff0da/vdae203_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf7/11969036/fdd983078a2b/vdae203_fig4.jpg

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[1]
Current trends in the allocation of National Institute of Health funding of brain tumor research.

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[2]
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[5]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Hotspots and Trends in Meningioma Research Based on Bibliometrics, 2011-2021.

World Neurosurg. 2024-3

[2]
Glioblastoma Immunotherapy: A Systematic Review of the Present Strategies and Prospects for Advancements.

Int J Mol Sci. 2023-10-10

[3]
Limited number of spine surgeons among recipients of National Institutes of Health grants awarded for degenerative spine disease research.

J Neurosurg Spine. 2023-12-1

[4]
Advances and trends in meningioma research over the last decade: A scientometric and visual analysis.

Front Oncol. 2023-3-8

[5]
Mortality trends in primary malignant brain and central nervous system tumors vary by histopathology, age, race, and sex.

J Neurooncol. 2023-3

[6]
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J Neurooncol. 2023-1

[7]
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JAMA Oncol. 2023-1-1

[8]
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J Neurooncol. 2022-10

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Neuro Oncol. 2022-10-5

[10]
Risk factors for pediatric glioma.

Folia Med (Plovdiv). 2022-8-31

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