Democritus University of Thrace, Alexandroupolis, Greece.
National and Kapodistrian University of Athens, Athens, Greece.
Folia Med (Plovdiv). 2022 Aug 31;64(4):566-571. doi: 10.3897/folmed..e64431.
Brain tumours are a heterogenic group, a subtype of which is arising from glial cells. Pediatric low-grade gliomas are the most common primary CNS tumour group in childhood, representing 25% to over 30% of pediatric CNS tumours. Pediatric high-grade gliomas are relatively rare and have a poor prognosis. Epidemiological studies have reported various potential risk factors, such as demographics, ionizing and nonionizing radiation, allergic conditions, and infections, immunologic, parental, genetic, and developmental risk factors. These risk factors are relatively unclear and understudied; thus, this narrative review aims to summarize all studies connecting risk factors and pediatric gliomas.
脑肿瘤是一组异质性肿瘤，其中一种起源于神经胶质细胞。小儿低级别胶质瘤是儿童中枢神经系统肿瘤中最常见的原发性肿瘤，占儿童中枢神经系统肿瘤的 25%以上，超过 30%。小儿高级别胶质瘤较为罕见，预后较差。流行病学研究报告了各种潜在的危险因素，如人口统计学、电离和非电离辐射、过敏情况、感染、免疫、父母、遗传和发育危险因素。这些危险因素尚不清楚，研究较少；因此，本叙述性综述旨在总结所有与小儿脑肿瘤危险因素相关的研究。
