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术前贫血增加髋部骨折后1年死亡的可能性。

Preoperative Anaemia Increases the Likelihood of 1-Year Mortality After Hip Fracture.

作者信息

Ferris Helena, Sedgwick Gavin, Marnane Mitchell, Clarke Sean, Dwyer Ann, Merron Georgia, Coughlan Tara

机构信息

Department of Public Health, Health Service Executive-South West, Cork, Ireland.

Department of Age-Related Health Care and Orthogeriatrics, Tallaght University Hospital, Dublin, Ireland.

出版信息

Adv Orthop. 2025 Mar 29;2025:5526883. doi: 10.1155/aort/5526883. eCollection 2025.

Abstract

Preoperative anaemia has been shown to increase the risk of adverse outcomes following hip fracture. To date, the association between haemoglobin (Hb) on admission and longer-term outcomes has not been studied extensively in the Irish hip fracture population. This study aimed to ascertain the mean Hb on admission and investigate the relationship with 1-year mortality. A retrospective review of all hip fracture cases in older adults discharged from an Irish urban trauma centre over a 4-year period was conducted. Hb on admission was obtained using electronic patient records. Mortality status was obtained via the Inpatient Management System and correlated with the Irish Death Events Register. Logistic regression was performed on a range of routinely collected patient and care pathway variables. A total of 833 patients were included. Mean Hb on admission was 12.1 g/dL (SD 1.7), with 11.4% (95/833) of patients having a Hb ≤ 10 g/dL. Within 1 year of fracture 20.5% (171/833) of patients had died. On multivariate analysis, those with a Hb ≤ 10 g/dL on admission were 76% more likely to die within one year (OR 1.76, < 0.02, 95% CI 1.07-2.90) compared to those with a Hb ≥ 10.1 g/dL. Patients admitted from a nursing home were also more likely to die within 1 year (OR 2.09, < 0.001, 95% CI 1.26-3.45), compared to those admitted from home. Early postoperative mobilisation (OR 0.32, < 0.001, 95% CI 0.22-0.48) and female gender (OR 0.49, < 0.001, 95% CI 0.34-0.71) reduced the likelihood of 1-year mortality (AUC 0.71). Anaemia is common in hip fracture patients and may be viewed as a surrogate marker of frailty. In this cohort, Hb ≤ 10 g/dL on admission was a statistically significant predictor of 1-year mortality. Recognising and managing anaemic patients preoperatively may provide an opportunity to improve longer-term outcomes in hip fracture patients.

摘要

术前贫血已被证明会增加髋部骨折后不良结局的风险。迄今为止,爱尔兰髋部骨折人群中入院时血红蛋白(Hb)水平与长期预后之间的关联尚未得到广泛研究。本研究旨在确定入院时的平均Hb水平,并调查其与1年死亡率的关系。对一家爱尔兰城市创伤中心4年内出院的所有老年髋部骨折病例进行了回顾性研究。通过电子病历获取入院时的Hb水平。通过住院管理系统获取死亡状态,并与爱尔兰死亡事件登记册进行关联。对一系列常规收集的患者和护理路径变量进行逻辑回归分析。共纳入833例患者。入院时平均Hb为12.1g/dL(标准差1.7),11.4%(95/833)的患者Hb≤10g/dL。骨折后1年内,20.5%(171/833)的患者死亡。多因素分析显示,入院时Hb≤10g/dL的患者在1年内死亡的可能性比Hb≥10.1g/dL的患者高76%(比值比1.76,P<0.02,95%置信区间1.07 - 2.90)。与从家中入院的患者相比,从养老院入院的患者在1年内死亡的可能性也更高(比值比2.09,P<0.001,95%置信区间1.26 - 3.45)。术后早期活动(比值比0.32,P<0.001,95%置信区间0.22 - 0.48)和女性性别(比值比0.49,P<0.001,95%置信区间0.34 - 0.71)可降低1年死亡率(曲线下面积0.71)。贫血在髋部骨折患者中很常见,可能被视为虚弱的替代指标。在该队列中,入院时Hb≤10g/dL是1年死亡率的统计学显著预测因素。术前识别和管理贫血患者可能为改善髋部骨折患者的长期预后提供机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3030/11972135/eb382737d2b6/AORTH2025-5526883.001.jpg

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