癌症干细胞特异性作为乳腺肿瘤治疗的新靶点。
Cancer stem cell specificity as new targets in breast tumor treatment.
作者信息
Zhang Zhizheng, Li Tao, Li Yuan, Wang X I, Liu Hao, Shen Xinyu, Xu Ann, Xia Tiansong, Xu B O
机构信息
Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Department of Pathology, Jiangsu Provincial People's Hospital, Nanjing, 210029, China.
出版信息
Oncol Res. 2025 Mar 19;33(4):811-819. doi: 10.32604/or.2024.050505. eCollection 2025.
BACKGROUND
Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy.
METHODS
This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as "breast cancer stem cells," "immunotherapy," "gene therapy," and "cell therapy." Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells.
RESULTS
Breast cancer stem cells exhibit unique properties that contribute to tumor initiation, progression, recurrence, and therapy resistance. Immunotherapy targeting breast cancer stem cells shows promise in overcoming these challenges, but issues such as lack of specificity and drug resistance need to be addressed.
CONCLUSIONS
Breast cancer stem cells represent promising targets for innovative therapeutic strategies aimed at improving treatment outcomes in breast cancer patients.
背景
乳腺癌是一种常见的影响女性的恶性肿瘤，治疗选择包括手术、放疗、化疗和内分泌治疗。
方法
本综述综合了关于乳腺癌干细胞及其在乳腺癌治疗中应用的现有文献。使用“乳腺癌干细胞”“免疫疗法”“基因疗法”和“细胞疗法”等关键词，对PubMed、科学网和其他相关数据库进行了系统检索。纳入以英文发表的研究，并对其结果进行分析，以深入了解乳腺癌干细胞的特征和治疗潜力。
结果
乳腺癌干细胞具有独特的特性，这些特性促成肿瘤的起始、进展、复发和治疗抵抗。针对乳腺癌干细胞的免疫疗法在克服这些挑战方面显示出前景，但缺乏特异性和耐药性等问题需要解决。
结论
乳腺癌干细胞是旨在改善乳腺癌患者治疗结果的创新治疗策略的有前景的靶点。
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