Polish validation of Parkinson's Disease non-motor questionnaire and clinical use in real life PD patients.
作者信息
Popławska-Domaszewicz Karolina, Florczak-Wyspianska Jolanta, Ambrosius Wojciech, Chaudhuri K Ray, Michalak Sławomir, Kozubski Wojciech
机构信息
Department for Neurology, Poznan University of Medical Sciences, Poznan, Poland.
Parkinson's Foundation Centre of Excellence, King's College Hospital, London, United Kingdom.
出版信息
Neurol Neurochir Pol. 2025;59(2):177-182. doi: 10.5603/pjnns.102113. Epub 2025 Apr 7.
AIM OF STUDY
To perform a linguistic translation using validated methodology of the Parkinson's Disease Non-motor Questionnaire (NMSQuest) in a Polish Parkinson's Disease (PD) population, and apply the Polish NMSQuest to a real-life PD population.
CLINICAL RATIONALE FOR STUDY
Non-motor symptoms are one of the key drivers of quality of life in PD patients and occur from the prodromal stage to the end palliative stage. Clinical recognition is crucial to manage these symptoms, and the PD NMSQuest is a globally used patient-completed validated PD-specific tool which helps to flag 30 common NMS in the clinic.
MATERIAL AND METHODS
Cognitive pretesting and linguistic translation were performed in 35 consecutive Polish PD patients using the translational programme recommended by the Movement Disorders Society. The validated and translated Polish version was then used in 70 consecutive PD patients (including the 35 original patients who performed the pretest) from outpatient clinics (43 males and 27 females). The mean age of the patients was 67.45 years (range 40-81) with a mean duration of PD of 12.32 years (range 2-24) and a median Hoehn and Yahr (HY) score of 3.
RESULTS
70 patients (mean age 67.45; mean duration of PD 12.32 years range 2-24; median HY score 3) provided 100% endorsement of the usefulness and need for using Polish NMSQuest using a cognitive pretest questionnaire. A subsequent study of the utility of the Polish NMSQuest showed it to be reliable across a large range of PD patients from 40-81 years and HY stages 1-4, with a mean declared NMS per patient of 6 across all stages of PD.
CONCLUSIONS AND CLINICAL IMPLICATIONS
The Polish version of the NMSQuest is reliable, valid and endorsed by Polish PD patients. Subsequent clinical use shows this to be a useful self- declaration flagging tool for NMS which needs to be captured in clinical visits so that clinical care includes management of NMS in PD.
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