Powers H J, Bates C J, Lamb W H
Hum Nutr Clin Nutr. 1985 Mar;39(2):117-29.
Eighty-one pregnant or lactating women living in a village in The Gambia were allocated to treatment groups to receive a daily placebo, riboflavin, ferrous sulphate or ferrous sulphate plus riboflavin. At the beginning of the study and at 3 and 6 weeks thereafter women were examined clinically and blood samples collected for haematological and biochemical measurements. Pregnant women showed a wide range of response to supplement but among the lactating women an interesting pattern emerged: whereas the haematological status of the placebo group declined over 6 weeks, in the group receiving iron supplements this deterioration was reduced although not significantly. Riboflavin given in addition to iron resulted in a significant increase in circulating plasma iron and in iron stores, relative to the placebo.
81名居住在冈比亚一个村庄的孕妇或哺乳期妇女被分配到各治疗组，分别每日服用安慰剂、核黄素、硫酸亚铁或硫酸亚铁加核黄素。在研究开始时以及之后的3周和6周，对这些妇女进行临床检查，并采集血样进行血液学和生化指标检测。孕妇对补充剂的反应差异很大，但在哺乳期妇女中出现了一个有趣的模式：安慰剂组的血液学指标在6周内下降，而在接受铁补充剂的组中，这种恶化有所减轻，尽管并不显著。相对于安慰剂，铁剂与核黄素联合使用使循环血浆铁和铁储备显著增加。
