Garijo-Toledo Magdalena, Alarcón-Elbal Pedro María, Montero Estefanía, Bravo-Barriga Daniel, Sansano-Maestre José, Ahuir-Baraja Ana Elena, Barragán Agustín, Viana David, Carbonell-Montes M Dolores, Barbero-Moyano Jesús, Martínez Remigio, García-Bocanegra Ignacio, Ortega Joaquín
Vector-Borne Diseases Research Group (ZOOVEC), Department of Animal Production and Health, Public Veterinary Health and Food Science and Technology, Faculty of Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Vector-Borne Diseases Research Group (ZOOVEC), Department of Animal Production and Health, Public Veterinary Health and Food Science and Technology, Faculty of Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Int J Parasitol. 2025 Jul;55(8-9):427-434. doi: 10.1016/j.ijpara.2025.04.002. Epub 2025 Apr 5.
Between December 2020 and March 2022, three cases of fatal meningoencephalitis were documented in two red-fronted brown lemurs (Eulemur rufus) and a ring-tailed lemur (Lemur catta) at the Bioparc in Valencia, eastern Spain. Post-mortem analyses revealed moderate congestion in the meninges of the brain in all cases. Multifocal areas of hemorrhage were observed in one lemur, primarily in the cerebellum and brainstem. Histopathological examination showed mainly acute hemorrhagic and necrotic changes, together with moderate eosinophilic and/or histiocytic meningoencephalitis, with perivascular cuffing, and gliosis. Numerous nematode larvae were found in the meninges, brain, and spinal cord, with or without associated inflammation, hemorrhage, and necrosis. Considering the affected host species, nematode morphology, and its anatomical localization, Angiostrongylus cantonensis (Nematoda: Metastrongylidae) was suspected as the causative agent. Phylogenetic studies based on the internal transcriber spacer 1/cytochrome c oxidase subunit I (ITS1/COI) genes confirmed the initial suspicion of this zoonotic parasite and its relationship to sequences from the Balearic and Canary Islands. This is the first known detection of A. cantonensis in non-human primates in Europe and it represents one of the few occurrences reported in the Palearctic region to date. Further research on this zoonotic parasite is crucial to understanding its spread in Spain, assessing public health risks, and developing effective control measures to mitigate outbreaks and protect human and animal health.
2020年12月至2022年3月期间，西班牙东部巴伦西亚生物公园的两只红额褐狐猴（Eulemur rufus）和一只环尾狐猴（Lemur catta）出现了三例致命性脑膜脑炎病例。尸检分析显示，所有病例的脑膜均有中度充血。在一只狐猴中观察到多灶性出血区域，主要位于小脑和脑干。组织病理学检查显示主要为急性出血性和坏死性改变，伴有中度嗜酸性和/或组织细胞性脑膜脑炎、血管周围套叠和胶质增生。在脑膜、脑和脊髓中发现了大量线虫幼虫，伴有或不伴有相关炎症、出血和坏死。考虑到受影响的宿主物种、线虫形态及其解剖定位，怀疑广州管圆线虫（线虫纲：后圆线虫科）为病原体。基于内部转录间隔区1/细胞色素c氧化酶亚基I（ITS1/COI）基因的系统发育研究证实了最初对这种人畜共患寄生虫的怀疑及其与巴利阿里群岛和加那利群岛序列的关系。这是欧洲首次在非人类灵长类动物中检测到广州管圆线虫，也是迄今为止在古北区报道的少数病例之一。对这种人畜共患寄生虫的进一步研究对于了解其在西班牙的传播、评估公共卫生风险以及制定有效的控制措施以减轻疫情和保护人类和动物健康至关重要。
