Li Xingping, Wang Wenqing, Liu Huanyu, Xia Ronghui, Lin Yang, Pan Guanghui
Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China.
Weifang NO. 2 People's Hospital, Weifang, Shandong, 261000, China.
Nutr Metab Cardiovasc Dis. 2025 Jun;35(6):104020. doi: 10.1016/j.numecd.2025.104020. Epub 2025 Mar 26.
Coronary heart disease (CHD) is the leading cause of severe cardiovascular events, such as acute myocardial infarction. This study investigates the interaction between serum 25-hydroxyvitamin D (25(OH)D) levels and CHD. However, most current studies are observational, which may introduce bias into the results.
We conducted a two-way, two-sample Mendelian randomization study. The CHD sample was drawn from the 2021 population in the FinnGen database (cases: 21,012; controls: 197,780), while the serum 25(OH)D sample was obtained from the 2020 European population in the GWAS Catalog database (417,580 cases). Based on the inverse variance weighted (IVW) results, we found that the risk of CHD decreased with increasing serum 25(OH)D concentrations (P < 0.05), and that higher CHD risk was associated with lower serum 25(OH)D concentrations (P = 0.04).
Our study found that increased serum 25(OH)D concentration may serve as a protective factor against CHD. Additionally, we found that CHD can be a risk factor that affects serum 25(OH)D concentrations in humans.
冠心病（CHD）是严重心血管事件（如急性心肌梗死）的主要原因。本研究调查血清25-羟基维生素D（25(OH)D）水平与冠心病之间的相互作用。然而，目前大多数研究都是观察性的，这可能会给结果带来偏差。
我们进行了一项双向、两样本孟德尔随机化研究。冠心病样本取自芬兰基因数据库2021年的人群（病例：21,012例；对照：197,780例），而血清25(OH)D样本来自全基因组关联研究目录数据库2020年的欧洲人群（417,580例）。基于逆方差加权（IVW）结果，我们发现冠心病风险随血清25(OH)D浓度升高而降低（P < 0.05），且冠心病风险越高与血清25(OH)D浓度越低相关（P = 0.04）。
我们的研究发现血清25(OH)D浓度升高可能是预防冠心病的保护因素。此外，我们发现冠心病可能是影响人体血清25(OH)D浓度的一个风险因素。
