Zubair Akmal, Ahmad Hanbal, Arif Muhammad Muaz, Ali Muhammad
Department of Biotechnology, Quaid-i-Azam University Islamabad, Islamabad, Pakistan.
HIV Med. 2025 Jun;26(6):824-838. doi: 10.1111/hiv.70024. Epub 2025 Apr 7.
Since the introduction of the first licensed mRNA-based vaccines against COVID-19, there has been significant interest in leveraging this technology for other vaccines. An unprecedented surge of mRNA vaccines has emerged in preclinical, clinical, and various research phases since 2020. The rapid development of mRNA formulations, delivery methods, and manufacturing processes has made this trend foreseeable. There is an urgent demand for effective and easily transportable vaccines in regions where the virus is prevalent, and mRNA technology shows promise in addressing this need.
The data was retrieved from various databases, including Google Scholar, PubMed, Science Direct, ClinicalTrials.gov, and government websites. The following terms were used in the search strategies: HIV, vaccines, mRNA vaccines, clinical trials, and preclinical trials. A total of 35 articles were identified and subsequently screened for data regarding mRNA vaccines for HIV.
mRNA vaccines are an effective solution for HIV treatment, as demonstrated by various research studies referenced in the article.
This review evaluates the current state of HIV-1 mRNA vaccine development, clarifies various targeting strategies, highlights recent research findings, and provides insights into the challenges and potential solutions associated with these issues. In this review, we have explored mRNA vaccines, focusing on their functional structure, design, manufacturing, and distribution methodologies.
自从首批获得许可的基于mRNA的新冠疫苗问世以来，人们对将该技术用于其他疫苗产生了浓厚兴趣。自2020年以来，在临床前、临床及各个研究阶段出现了前所未有的mRNA疫苗研发热潮。mRNA制剂、递送方法和生产工艺的迅速发展使这一趋势具有可预见性。在病毒流行地区，对有效且易于运输的疫苗有着迫切需求，而mRNA技术在满足这一需求方面显示出前景。
数据从多个数据库检索获得，包括谷歌学术、PubMed、科学Direct、临床试验.gov和政府网站。搜索策略中使用了以下术语：HIV、疫苗、mRNA疫苗、临床试验和临床前试验。共识别出35篇文章，随后筛选有关HIV的mRNA疫苗的数据。
正如文章中引用的各种研究表明，mRNA疫苗是治疗HIV的有效解决方案。
本综述评估了HIV-1 mRNA疫苗的研发现状，阐明了各种靶向策略，突出了近期研究成果，并深入探讨了与这些问题相关的挑战及潜在解决方案。在本综述中，我们探讨了mRNA疫苗，重点关注其功能结构、设计、生产和分发方法。
