Fan Yumei, Wei Chunhua, Su Ning, Ma Yanyun, Liu Wei, Sun Peiwen, Shan Shuo
Shin Biotechnology Co., Ltd, Shanghai, China.
Chinese Academy of Inspection and Quarantine, Beijing, China.
Int J Cosmet Sci. 2025 Apr 7. doi: 10.1111/ics.13065.
Changes in the stratum corneum (SC) lipid profiles are associated with various skin diseases. Factors, including age, ethnicity, season and anatomical location, can influence the variations in SC lipid profiles. According to reports, the facial sebum of Chinese women peaks at age 20-30, accompanied by various signs of facial ageing. No studies have investigated how facial SC lipid profiles change with age in young Chinese women.
This study aimed to observe the differences in the facial SC lipid profiles of Chinese female volunteers aged 19-33 and determined the relationship between key lipids and physiological parameters.
Differential lipids were detected and screened in healthy Chinese women aged 19-33 through ultra-performance liquid chromatography-mass spectrometry. The relationship between these lipids and the skin's physiological parameters was determined.
The facial SC lipid profiles of young Chinese women exhibited significant differences with age. The results indicated that 40 lipids increased with age, while 51 types decreased. The average chain length of diglycerides (DG), triglycerides (TG) and short-chain ceramides decreased with age, while cholesterol esters (CE) and ceramides {Cer, Cer/EODS (d19:0/18:1/O/16:0) and Cer/EOS (d28:1/12:0/O/14:0)} increased with age. Cer/EODS (d19:0/18:1/O/16:0), Cer/EOS (d28:1/12:0/O/14:0) and HexCer/NDS (d14:0/33:1) were positively correlated with trans-epidermal water loss, skin elasticity and skin brightness, while Cer/AP (t18:0/20:0) was negatively correlated with skin elasticity. This study comprehensively explains the differences in lipid profile composition and skin ageing in young populations.
Young Chinese women's facial skin SC lipid profiles significantly change with age. Age-related changes result in variations in DG and CE levels and changes in the chain lengths of TG and Cer. Age-related changes in Cer content affect skin barrier function, elasticity and brightness.
角质层（SC）脂质谱的变化与多种皮肤疾病相关。年龄、种族、季节和解剖位置等因素会影响SC脂质谱的变化。据报道，中国女性面部皮脂在20 - 30岁达到峰值，同时伴有各种面部衰老迹象。尚无研究调查中国年轻女性面部SC脂质谱如何随年龄变化。
本研究旨在观察19 - 33岁中国女性志愿者面部SC脂质谱的差异，并确定关键脂质与生理参数之间的关系。
通过超高效液相色谱 - 质谱法对19 - 33岁健康中国女性的差异脂质进行检测和筛选。确定这些脂质与皮肤生理参数之间的关系。
中国年轻女性面部SC脂质谱随年龄呈现显著差异。结果表明，40种脂质随年龄增加，而51种脂质减少。甘油二酯（DG）、甘油三酯（TG）和短链神经酰胺的平均链长随年龄减小，而胆固醇酯（CE）和神经酰胺{神经酰胺（Cer）、神经酰胺/醚键型神经鞘氨醇（d19:0/18:1/O/16:0）和神经酰胺/醚键型神经鞘氨醇（d28:1/12:0/O/14:0）}随年龄增加。神经酰胺/醚键型神经鞘氨醇（d19:0/18:1/O/16:0）、神经酰胺/醚键型神经鞘氨醇（d28:1/12:0/O/14:0）和己糖神经酰胺/非二氢鞘氨醇（d14:0/33:1）与经表皮水分流失、皮肤弹性和皮肤亮度呈正相关，而神经酰胺/酰胺键型神经鞘氨醇（t18:0/20:0）与皮肤弹性呈负相关。本研究全面解释了年轻人群脂质谱组成差异和皮肤衰老情况。
中国年轻女性面部皮肤SC脂质谱随年龄显著变化。与年龄相关的变化导致DG和CE水平的改变以及TG和神经酰胺链长的变化。神经酰胺含量与年龄相关的变化影响皮肤屏障功能、弹性和亮度。
