Melchior Chloé, Hreinsson Jóhann P, Tack Jan, Keller Jutta, Aziz Qasim, Palsson Olafur S, Bangdiwala Shrikant I, Sperber Ami D, Simrén Magnus, Sabaté Jean-Marc
Department of Gastroenterology, Univ Rouen Normandie, INSERM, ADEN UMR1073 "Nutrition, Inflammation and Microbiota-Gut-Brain Axis", CHU Rouen, CIC-CRB 1404, Rouen, France.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
United European Gastroenterol J. 2025 Jul;13(6):917-928. doi: 10.1002/ueg2.12700. Epub 2025 Apr 7.
The prevalence of disorders of the gut-brain interaction (DGBI) among people with obesity in the general population is unknown. Our aim was to assess the prevalence of DGBI among obese subjects in the general population in comparison with normal or overweight subjects, as well as exploring factors associated with DGBI in obesity in Europe.
We included subjects who completed the internet-based survey of the Rome Foundation Global Epidemiology study in 11 European countries. Obesity was defined as a BMI>30 kg/m and participants were divided into three classes: 1: BMI 30 to <35 kg/m, 2: BMI 35 to <40 kg/m, and 3: BMI 40 kg/m or higher. The prevalence of symptoms compatible with DGBI was reported and compared between obese and normal or overweight (BMI between 18.5 and <30 kg/m) participants. Factors potentially associated with DGBI and obesity including demographics, psychological distress (PHQ-4), non-GI somatic symptoms (PHQ-12), quality of life (PROMIS-10), healthcare access, medication and food consumption were assessed.
We included 20,117 participants in our analysis. The prevalence of obesity was 17.8% (95% CI 17.3, 18.4), with 12.6%, 3.7% and 1.6% in obesity classes 1, 2 and 3, respectively. The prevalence of any DGBI was 44.2% in the obese group versus 39.6% in the normal or overweight group (OR = 1.20 (1.12, 1.30)), with all DGBI being more prevalent in the obese versus normal or overweight group, with the exception for functional constipation where the opposite pattern was seen. Female sex, higher level of psychological distress and more severe non-GI somatic symptoms were seen in the group with DGBI associated with obesity.
Symptoms compatible with DGBI are common among European people with obesity in the general population and are linked with certain demographic and disease-related factors. This should be acknowledged in the management of patients with obesity.
普通人群中肥胖者肠道-脑互动障碍（DGBI）的患病率尚不清楚。我们的目的是评估普通人群中肥胖受试者与正常或超重受试者相比DGBI的患病率，并探索欧洲肥胖人群中与DGBI相关的因素。
我们纳入了在11个欧洲国家完成罗马基金会全球流行病学研究基于互联网调查的受试者。肥胖定义为BMI>30kg/m²，参与者分为三类：1：BMI 30至<35kg/m²，2：BMI 35至<40kg/m²，3：BMI 40kg/m²或更高。报告了与DGBI相符的症状患病率，并在肥胖与正常或超重（BMI在18.5至<30kg/m²之间）参与者之间进行比较。评估了可能与DGBI和肥胖相关的因素，包括人口统计学、心理困扰（PHQ-4）、非胃肠道躯体症状（PHQ-12）、生活质量（PROMIS-10）、医疗保健获取、用药和食物消费情况。
我们的分析纳入了20117名参与者。肥胖患病率为17.8%（95%CI 17.3，18.4），其中肥胖1、2、3类分别为12.6%、3.7%和1.6%。肥胖组中任何DGBI的患病率为44.2%，而正常或超重组为39.6%（OR = 1.20（1.12，1.30）），所有DGBI在肥胖组中比正常或超重组更普遍，但功能性便秘除外，其情况相反。在与肥胖相关的DGBI组中，女性、心理困扰程度较高和非胃肠道躯体症状较严重的情况更为常见。
与DGBI相符的症状在普通人群中的欧洲肥胖者中很常见，并且与某些人口统计学和疾病相关因素有关。在肥胖患者的管理中应认识到这一点。
