Yanping Wu, Gao Xuefen, Cheng Yizun, Liu Mi, Liao Siyu, Zhou Jing, Hao Jiaming, Jiang Gemeng, Lu Yixuan, Qu Tianyao, Qin Bin, Cheng Yan
Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Gastroenterol Hepatol. 2023 Mar;38(3):370-377. doi: 10.1111/jgh.16083. Epub 2022 Dec 14.
Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.
肥胖是一个全球性问题，与多种慢性疾病相关，如心血管疾病、2型糖尿病和代谢紊乱。它也可能在内脏超敏反应中起作用，导致肠易激综合征。(i) 脂肪组织分泌各种炎症介质，导致肠道通透性增加和神经末梢激活。(ii) 肥胖与胃肠道微生物群相互影响，微生物代谢产物可增加结肠的敏感性。(iii) 维生素D缺乏会导致脂肪堆积和肠黏膜屏障破坏。(iv) 脑-肠轴可能是肥胖与内脏超敏反应之间的另一个桥梁。
