Hu Xianwen, Yang Peqing, Mei Tengyue, Cai Jiong, Wang Pan
Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
Sci Rep. 2025 Apr 7;15(1):11821. doi: 10.1038/s41598-025-95971-2.
Intermediate bone tumor has a certain risk of invasion and metastasis, but its invasion degree and metastasis probability are much lower than malignant bone tumor. The objective of this study was to retrospectively analyze F-FDG PET/CT findings in patients with spinal intermediate tumors. A total of 49 patients with spinal intermediate tumors consisting of 22 giant cell tumor of bone (GCTB), 11 osteoblastoma, 10 Langerhans cell histiocytosis (LCH) and 6 epithelioid hemangioma were subjected to evaluation using F-FDG PET/CT. Factors analyzed included lesion location, size, epicenter of the lesions (vertebral/posterior elements), eccentric expansile osteolysis, cortical integrity, residual bone trabeculae/spine/calcification, sclerotic rim, vertebral compression, soft tissue mass, and maximum standard uptake value (SUVmax) of lessions. GCTB, osteoblastoma, LCH, and epithelioid hemangioma showed statistically significant differences in the main body of the lesion, maximum diameter, eccentric expansile osteolysis, cortical integrity, residual bone trabeculae/spine/calcification, sclerosal margin, vertebral compression, and lesions' SUVmax (p < 0.05). GCTB has a higher SUVmax, significantly higher than that of osteoblastoma and LCH (p < 0.05). Spinal GCTB, osteoblastoma, LCH, and epithelioid hemangioma have certain F-FDG PET/CT features, and F-FDG PET/CT may contribute to differentiate them from each other.
中间型骨肿瘤具有一定的侵袭和转移风险，但其侵袭程度和转移概率远低于恶性骨肿瘤。本研究的目的是回顾性分析脊柱中间型肿瘤患者的F-FDG PET/CT表现。共有49例脊柱中间型肿瘤患者接受了F-FDG PET/CT评估，其中包括22例骨巨细胞瘤（GCTB）、11例骨母细胞瘤、10例朗格汉斯细胞组织细胞增多症（LCH）和6例上皮样血管瘤。分析的因素包括病变位置、大小、病变中心（椎体/后部结构）、偏心膨胀性骨质溶解、皮质完整性、残余骨小梁/脊柱/钙化、硬化边缘、椎体压缩、软组织肿块以及病变的最大标准摄取值（SUVmax）。GCTB、骨母细胞瘤、LCH和上皮样血管瘤在病变主体、最大直径、偏心膨胀性骨质溶解、皮质完整性、残余骨小梁/脊柱/钙化、硬化边缘、椎体压缩以及病变的SUVmax方面存在统计学显著差异（p < 0.05）。GCTB的SUVmax较高，显著高于骨母细胞瘤和LCH（p < 0.05）。脊柱GCTB、骨母细胞瘤、LCH和上皮样血管瘤具有一定的F-FDG PET/CT特征，F-FDG PET/CT可能有助于它们之间的鉴别。
