Shu Wanqiong, Huang Guanghong
Affiliated Guangdong Hospital of Integrated Traditional Chinese and Western Medicine of Guangzhou University of Chinese Medicine, No.16, Guicheng South Fifth Road, Nanhai District, Foshan, 528200, China.
Sci Rep. 2025 Apr 7;15(1):11873. doi: 10.1038/s41598-025-96111-6.
Although inflammatory bowel disease (IBD) has been linked to cardiovascular disease in a growing body of literature, the relationship between IBD and arrhythmia remains unclear. To investigate the causal relationship between inflammatory bowel disease and arrhythmia, we conducted this Mendelian randomization (MR) analysis. We identified single nucleotide polymorphisms (SNP) associated with IBD as instruments, including IBD, ulcerative colitis (UC), and Crohn's disease (CD). SNPs of two arrhythmia phenotypes as outcome data, namely atrioventricular block (AVB), and paroxysmal tachycardia (PTA). The inverse variance weighting method was used to analyze the two-sample Mendelian randomization with four other methods, including MR Egger, Weighted median, Simple mode, and Weighted mode. Sensitivity analysis involves different methods to detect and adjust for bias in results, including heterogeneity analysis, pleiotropy analysis, and leave-one-out sensitivity analysis. To ensure the rigor of the analysis results, we selected another set of exposure data sets and conducted the MR verification analysis using the same method. Results suggested UC is significantly associated with an increased risk of AVB (odds ratio, OR 1.178, 95% CI 1.070-1.297, P = 0.000828), the verification analysis results are consistent with this (OR 1.048, 95% CI 1.007-1.091, P = 0.022947). Our study suggests a potential risk increase of atrioventricular block in patients with UC. These results also provide further evidence that inflammatory bowel disease may increase the risk of developing arrhythmia.
尽管越来越多的文献表明炎症性肠病（IBD）与心血管疾病有关，但IBD与心律失常之间的关系仍不明确。为了研究炎症性肠病与心律失常之间的因果关系，我们进行了这项孟德尔随机化（MR）分析。我们确定了与IBD相关的单核苷酸多态性（SNP）作为工具变量，包括IBD、溃疡性结肠炎（UC）和克罗恩病（CD）。将两种心律失常表型的SNP作为结果数据，即房室传导阻滞（AVB）和阵发性心动过速（PTA）。采用逆方差加权法与其他四种方法进行两样本孟德尔随机化分析，包括MR Egger法、加权中位数法、简单模式法和加权模式法。敏感性分析采用不同方法检测和校正结果中的偏倚，包括异质性分析、多效性分析和留一法敏感性分析。为确保分析结果的严谨性，我们选择了另一组暴露数据集，并使用相同方法进行MR验证分析。结果表明，UC与AVB风险增加显著相关（优势比，OR 1.178，95%CI 1.070-1.297，P = 0.000828），验证分析结果与此一致（OR 1.048，95%CI 1.007-1.091，P = 0.022947）。我们的研究表明UC患者发生房室传导阻滞的潜在风险增加。这些结果也进一步证明炎症性肠病可能增加发生心律失常的风险。
