Glazebrook G A, Jackson F I, Usiskin S R
J Can Assoc Radiol. 1985 Jun;36(2):127-32.
The influence of flowing blood on temperatures reached in nearby tumor cells during localized radiofrequency (RF) hyperthermia may be critical for tumor cell survival. We have investigated the effect on the temperatures nearby of blood flowing in a vessel. Using 13.56 MHz capacitive RF, we heated gel phantoms containing a tube through which cooling solution could flow. Our results demonstrated a reduction in temperature of the order of 3 degrees C around the tube when coolant was flowing, and the cooling pattern correlated with theoretical mathematical predictions. Up to 564 joules per minute could be removed from the system. Our results suggest the improbability of uniform tumor cell killing by RF heating. A scheme for integrating the concepts of physical cell damage, biochemical cell damage and peripheral cell survival in a tumor nodule is presented.
在局部射频（RF）热疗过程中，流动的血液对附近肿瘤细胞所达到的温度的影响可能对肿瘤细胞的存活至关重要。我们研究了血管中血液流动对附近温度的影响。使用13.56兆赫的电容性射频，我们加热了含有一根冷却溶液可从中流过的管子的凝胶体模。我们的结果表明，当冷却剂流动时，管子周围的温度降低了约3摄氏度，并且冷却模式与理论数学预测相关。每分钟最多可从系统中移除564焦耳。我们的结果表明，通过射频加热均匀杀死肿瘤细胞不太可能。本文提出了一种将肿瘤结节中物理性细胞损伤、生化性细胞损伤和周边细胞存活的概念整合起来的方案。
