Anderson G, Ye X, Henle K, Yang Z, Li G
Department of Electronics and Instrumentation, University of Arkansas at Little Rock.
Int J Biomed Comput. 1994 May;35(4):297-307.
Hyperthermia is a promising adjuvant cancer treatment modality. However, unresolved engineering problems with the production and regulation of temperature distributions within tissues in vivo have frustrated repeated efforts to implement clinical hyperthermia protocols. A major technical problem with hyperthermia production in vivo is the cooling effect caused by circulating blood in larger vessels. Larger blood vessels, when located in heated tumors, can prevent achievement of sufficiently high temperatures, resulting in loss of therapeutic effect. One possible way of circumventing this problem is the delivery of a critical heat dose during a short-term, high-temperature treatment episode to minimize cooling from blood flow. We investigated the concept of such rapid, high-temperature heating of tissue in a two-dimensional finite element numerical model. The model demonstrates the feasibility of interstitial radiofrequency delivery of a therapeutic heat dose, equivalent to 30 min at 43 degrees C, to a 1 cm3 tumor during a 60-s period. The model assumes circulation of cooling fluid through hollow electrodes. A post processor has been designed to display a 3-D image of the temperature distribution, electric field, and thermal dose delivered to a unit volume within the heated tissue.
热疗是一种很有前景的癌症辅助治疗方式。然而，体内组织温度分布的产生和调节方面尚未解决的工程问题，使得实施临床热疗方案的反复努力受挫。体内热疗产生的一个主要技术问题是较大血管中循环血液引起的冷却效应。较大的血管位于受热肿瘤中时，会阻止达到足够高的温度，导致治疗效果丧失。规避此问题的一种可能方法是在短期高温治疗过程中给予临界热剂量，以尽量减少血流造成的冷却。我们在二维有限元数值模型中研究了这种对组织进行快速高温加热的概念。该模型证明了在60秒内通过间质射频向1立方厘米肿瘤输送相当于43摄氏度下30分钟的治疗热剂量的可行性。该模型假定冷却流体通过空心电极循环。已设计了一个后处理器来显示温度分布、电场以及输送到受热组织内单位体积的热剂量的三维图像。
