Wu Chenguang, Xu Zhenyan, Chen Xin, Liu Hualong, Chen Yuliang, Huang Jiaxing, Lu Teng, Huang Zixi
Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Department of Health Care, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Front Nutr. 2025 Mar 24;12:1504855. doi: 10.3389/fnut.2025.1504855. eCollection 2025.
The relationship between fasting blood glucose and urea in non-diabetic individuals is still unclear. This study aimed to evaluate the association between fasting blood glucose and urea in a non-diabetic population.
Data from a cohort of non-diabetic individuals were collected from the 2009 China Health and Nutrition Survey dataset. We performed smooth curve and two piecewise linear regression analyses to assess the association between fasting blood glucose and urea in this non-diabetic population.
Data from a total of 7,596 adult participants without diabetes were included in this study; the mean age of the participants was 50.2 years, and 46.4% were male. There was an L-shaped relationship between fasting blood glucose and urea, and the inflection point of fasting blood glucose was 4.6 mmol/L. After adjusting for potential confounders, we found a negative correlation between fasting blood glucose and urea up to the inflection point (β = -0.3, 95% CI -0.5 to -0.2, < 0.001), but beyond the inflection point, this relationship disappeared (β = 0.0, 95% CI -0.1 to 0.1 = 0.848). In the group with lower fasting blood glucose (fasting blood glucose <4.6 mmol/L), smoking (interaction = 0.037) and alcohol consumption (interaction = 0.001) influenced the relationship between fasting blood glucose and urea.
The results suggest that lower fasting blood glucose was associated with higher urea in non-diabetic individuals with fasting blood glucose <4.6 mmol/L, revealing an L-shaped association between fasting blood glucose and urea.
非糖尿病个体的空腹血糖与尿素之间的关系仍不明确。本研究旨在评估非糖尿病人群中空腹血糖与尿素之间的关联。
从2009年中国健康与营养调查数据集收集非糖尿病个体队列的数据。我们进行了平滑曲线和两段式线性回归分析，以评估该非糖尿病人群中空腹血糖与尿素之间的关联。
本研究纳入了总共7596名无糖尿病的成年参与者的数据；参与者的平均年龄为50.2岁，46.4%为男性。空腹血糖与尿素之间呈L形关系，空腹血糖的拐点为4.6 mmol/L。在调整潜在混杂因素后，我们发现直至拐点空腹血糖与尿素呈负相关（β = -0.3，95%置信区间 -0.5至-0.2，P < 0.001），但超过拐点后，这种关系消失（β = 0.0，95%置信区间 -0.1至0.1，P = 0.848）。在空腹血糖较低的组（空腹血糖<4.6 mmol/L）中，吸烟（交互作用P = 0.037）和饮酒（交互作用P = 0.001）影响空腹血糖与尿素之间的关系。
结果表明，在空腹血糖<4.6 mmol/L的非糖尿病个体中，较低的空腹血糖与较高的尿素相关，揭示了空腹血糖与尿素之间的L形关联。
