Wang Yunyang, Chi Jingwei, Che Kui, Chen Ying, Sun Xiaolin, Wang Yangang, Wang Zhongchao
Department of Endocrinology & Metabolism, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
PLoS One. 2017 Jun 28;12(6):e0180111. doi: 10.1371/journal.pone.0180111. eCollection 2017.
Although several epidemiological studies assessed the relationship between fasting plasma glucose (FPG) and serum uric acid (SUA) levels, the results were inconsistent. A cross-sectional study was conducted to investigate this relationship in Chinese individuals with normal glucose tolerance.
A total of 5,726 women and 5,457 men with normal glucose tolerance were enrolled in the study. All subjects underwent a 75-g oral glucose tolerance test. Generalized additive models and two-piecewise linear regression models were applied to assess the relationship.
A U-shaped relationship between FPG and SUA was observed. After adjusting for potential confounders, the inflection points of FPG levels in the curves were 4.6 mmol/L in women and 4.7 mmol/L in men respectively. SUA levels decreased with increasing fasting plasma glucose concentrations before the inflection points (regression coefficient [β] = -36.4, P < 0.001 for women; β = -33.5, P < 0.001 for men), then SUA levels increased (β = 17.8, P < 0.001 for women; β = 13.9, P < 0.001 for men). Additionally, serum insulin levels were positively associated with FPG and SUA (P < 0.05).
A U-shaped relationship between FPG and SUA levels existed in Chinese individuals with normal glucose tolerance. The association is partly mediated through serum insulin levels.
尽管多项流行病学研究评估了空腹血糖（FPG）与血清尿酸（SUA）水平之间的关系，但结果并不一致。本横断面研究旨在调查糖耐量正常的中国人群中的这种关系。
共有5726名女性和5457名男性糖耐量正常者纳入本研究。所有受试者均接受了75克口服葡萄糖耐量试验。应用广义相加模型和两段式线性回归模型评估二者关系。
观察到FPG与SUA之间呈U型关系。在调整潜在混杂因素后，曲线中FPG水平的拐点女性为4.6 mmol/L，男性为4.7 mmol/L。在拐点之前，SUA水平随空腹血糖浓度升高而降低（回归系数[β]：女性为 -36.4，P < 0.001；男性为 -33.5，P < 0.001），之后SUA水平升高（β：女性为17.8，P < 0.001；男性为13.9，P < 0.001）。此外，血清胰岛素水平与FPG和SUA呈正相关（P < 0.05）。
糖耐量正常的中国人群中，FPG与SUA水平之间存在U型关系。这种关联部分通过血清胰岛素水平介导。
