一例因自我注射聚乙二醇化赛妥珠单抗导致的腹直肌鞘血肿病例。
A Case of Rectus Sheath Hematoma Caused by Self-Injection of Certolizumab Pegol.
作者信息
Suenaga Atsuhiko, Hashimoto Yuka, Kanaya Akiko, Fukunari Kennichi, Kawahara Yasuhiro, Miyazono Motoaki
机构信息
Department of Nephrology, National Hospital Organization Ureshino Medical Center, Ureshino, JPN.
Division of Nephrology, Saga University Faculty of Medicine, Saga, JPN.
出版信息
Cureus. 2025 Mar 6;17(3):e80154. doi: 10.7759/cureus.80154. eCollection 2025 Mar.
Rectus sheath hematoma (RSH) is a condition caused by hemorrhage into the rectus sheath. A 61-year-old man with end-stage renal failure and rheumatoid arthritis presented to our hospital with abdominal pain. The patient had been receiving biweekly self-injections of certolizumab pegol to the abdominal wall. Computed tomography (CT) demonstrated a large high-density left-sided RSH. Abdominal pain gradually exacerbated; thus, transcatheter arterial embolization (TAE) for the left inferior epigastric artery (IEA) was performed. This is the first reported case of RSH caused by certolizumab pegol. Factors contributing to RSH include low abdominal wall fat, the use of auto-injector-based preparations, and anticoagulant use in dialysis.
腹直肌鞘血肿（RSH）是一种由血液流入腹直肌鞘引起的病症。一名患有终末期肾衰竭和类风湿性关节炎的61岁男性因腹痛前来我院就诊。该患者一直在腹壁进行每两周一次的赛妥珠单抗聚乙二醇自我注射。计算机断层扫描（CT）显示左侧有一个巨大的高密度腹直肌鞘血肿。腹痛逐渐加剧；因此，对左腹壁下动脉（IEA）进行了经导管动脉栓塞术（TAE）。这是首例由赛妥珠单抗聚乙二醇引起的腹直肌鞘血肿报告病例。导致腹直肌鞘血肿的因素包括下腹部壁脂肪少、使用基于自动注射器的制剂以及在透析中使用抗凝剂。
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