Sultana Evana, Rana Md Zewel, Mamun Muhammad Shamim Al, Aly Saad Aly Mohamed, Khedr Ghada E, Nasiruddin Md, Khan Md Zaved Hossain
Chemistry Discipline, Khulna University Khulna-9208 Bangladesh
Chemical & Materials Engineering, University of Nevada Reno, 1664 North Virginia Street Reno NV 89557 USA.
RSC Adv. 2025 Apr 7;15(13):10442-10452. doi: 10.1039/d5ra00067j. eCollection 2025 Mar 28.
Formalin, an organic chemical containing a mixture of carbon, hydrogen, and oxygen, is a formaldehyde solution in water that is widely used as a preservative because of its antibacterial qualities. Despite being used to extend the shelf life and conceal product deterioration, it may be harmful to customers. In light of these factors, a portable, sensitive, accurate, and user-friendly platform for formalin detection is suggested here. The present study utilizes a colorimetric approach that involves the use of disodium ethylenediaminetetraacetic acid (EDTA)-capped gold nanoparticles (AuNPs) and a smartphone. A cotton pad with AuNaEDTA integrated served as the substrate for formalin adsorption. The colorimetric image is then converted into RGB values using the graphical editor software, GNU Image Manipulation Program (GIMP), to detect formalin. A noticeable color shift was seen during the detection process: the hue changed from red-wine to purplish-blue as the formalin content rose, indicating the development of the AuNaEDTA-HCHO complex. This result provides a low detection limit of 0.11 μM and a sensitive linear correlation between 1/ values and various formalin concentrations, with a linear fit coefficient of 0.99607. The present study represents the first attempt, to the best of our knowledge, to report on the experimental activation energy of gold nanoparticles capped with NaEDTA as well as the application of this nanostructure as a formalin detection platform. The developed system has a great potential of being used in clinical settings for the detection of formalin.
福尔马林是一种含有碳、氢和氧混合物的有机化学品，是一种甲醛水溶液，因其抗菌特性而被广泛用作防腐剂。尽管它被用于延长保质期和掩盖产品变质，但可能对消费者有害。鉴于这些因素，本文提出了一种用于福尔马林检测的便携式、灵敏、准确且用户友好的平台。本研究采用了一种比色法，该方法涉及使用乙二胺四乙酸二钠（EDTA）包覆的金纳米颗粒（AuNPs）和智能手机。集成了AuNaEDTA的棉垫用作福尔马林吸附的底物。然后使用图形编辑软件GNU图像处理程序（GIMP）将比色图像转换为RGB值，以检测福尔马林。在检测过程中观察到明显的颜色变化：随着福尔马林含量的增加，色调从红酒色变为紫蓝色，表明形成了AuNaEDTA - HCHO络合物。该结果提供了0.11 μM的低检测限以及1/值与各种福尔马林浓度之间的灵敏线性相关性，线性拟合系数为0.99607。据我们所知，本研究首次尝试报告NaEDTA包覆的金纳米颗粒的实验活化能以及这种纳米结构作为福尔马林检测平台的应用。所开发的系统在临床环境中用于福尔马林检测具有很大的潜力。
