用高效液相色谱法测定去铁胺及其一种主要代谢物。在铝相关疾病治疗中的应用。
Determination of desferoxamine and a major metabolite by high-performance liquid chromatography. Application to the treatment of aluminium-related disorders.
作者信息
Kruck T P, Kalow W, McLachlan D R
出版信息
J Chromatogr. 1985 May 31;341(1):123-30. doi: 10.1016/s0378-4347(00)84016-5.
PMID:4019677
Abstract
A high-performance liquid chromatography method is described that permits separation and quantification of desferoxamine, a major metabolite, the iron(III) and the aluminum(III) chelates of desferoxamine. This method now facilitates pharmacokinetic studies on desferoxamine and derivatives designed to study side-effects and metabolite patterns in patients undergoing treatment.
摘要
本文描述了一种高效液相色谱法，该方法可对去铁胺、一种主要代谢物、去铁胺的铁（III）和铝（III）螯合物进行分离和定量。该方法现在有助于对去铁胺及其衍生物进行药代动力学研究，这些衍生物旨在研究接受治疗的患者的副作用和代谢物模式。
Zotero 插件