Tsuzuki H, Kitamura H
J Craniofac Genet Dev Biol. 1985;5(2):209-21.
The recombinants of the mandibular molar bud epithelia with cranial ectomesenchymal cell groups from several different sources--mandibular molar area, tongue anlagen, and lateral nasal process--were cultured. Dental laminalike buds were developed in each of the recombinants (incidence of development 38-86%). In the heterotrophic recombinants, heterotypic differentiation of mandibular epithelium was also induced. However, the foreign ectomesenchymal cells were not induced heterotypically by the epithelial genetic factor, but the mesenchymal genetic factor is maintained. It is suggested that mandibular molar bud epithelia have potency to proliferate into mesenchyme under non-organ-specific influences of ectomesenchymal cells and that presumptive mandibular mucosal epithelia have multipotency for differentiation sensitive to inductive influences by the heterotypic cranial ectomesenchymal cells but that the mandibular molar bud epithelia have no heterotypic inductive activity for the differentiation of cranial ectomesenchymal cells.
将下颌磨牙牙胚上皮与来自几个不同来源（下颌磨牙区、舌原基和外侧鼻突）的颅外间充质细胞群进行重组培养。每个重组体中都形成了牙板样牙胚（发育发生率为38%-86%）。在异位重组体中，下颌上皮也发生了异型分化。然而，外来的间充质细胞并未被上皮遗传因子诱导发生异型分化，而是维持了间充质遗传因子。这表明下颌磨牙牙胚上皮在颅外间充质细胞的非器官特异性影响下具有向间充质增殖的能力，推测下颌黏膜上皮对异型颅外间充质细胞的诱导影响具有多能分化性，但下颌磨牙牙胚上皮对颅外间充质细胞的分化没有异型诱导活性。
