Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, Maastricht 6229 ER, The Netherlands.
Cardiovasc Res. 2012 Mar 15;93(4):605-13. doi: 10.1093/cvr/cvr268. Epub 2011 Oct 11.
With a progressively growing elderly population, ageing-associated pathologies such as cardiovascular diseases are becoming an increasing economic, social, and personal burden for Western societies. Interestingly, all ageing-associated diseases share a common denominator: inflammation. Recently, microRNAs were shown to be implicated in the full range of processes of ageing, inflammation, and cardiovascular diseases. This review focuses on their role in cardiovascular diseases with emphasis on their implication in the inflammatory processes that accompany heart failure, atherosclerosis, coronary artery disease, and finally obesity and diabetes as components of the ageing-associated metabolic syndrome.
随着老年人口的不断增长，与衰老相关的疾病，如心血管疾病，正成为西方社会日益沉重的经济、社会和个人负担。有趣的是，所有与衰老相关的疾病都有一个共同的特征：炎症。最近，microRNAs 被证明与衰老、炎症和心血管疾病的全过程有关。这篇综述重点讨论了它们在心血管疾病中的作用，强调了它们在心衰、动脉粥样硬化、冠心病以及肥胖和糖尿病等与衰老相关的代谢综合征成分中伴随的炎症过程中的作用。
