Abdelgadir Elamin, Rashid Fauzia, Bashier Alaaeldin, Zidan Marwan, McGowan Barbara, Alawadi Fatheya
Endocrinology Department, Mohamed Bin Rashid University, Dubai, United Arab Emirates.
Endocrinology Department, Dubai Academic Health Corporation, Dubai Hospital, Dubai, United Arab Emirates.
Diabetes Obes Metab. 2025 Jul;27(7):3676-3685. doi: 10.1111/dom.16389. Epub 2025 Apr 8.
Although there are population-level estimates of the prevalence of overweight and obesity (OAO), there are few direct epidemiological surveys of OAO prevalence at scale.
This was a cross-sectional, multi-centre, population-based study of all adults aged >18 years attending the Dubai Academic Health Corporation (DAHC) between January 2018 and August 2023. OAO was defined according to WHO standards or modified WHO cut points for individuals from WHO South-East Asian Region (SEAR) countries. Clinical obesity, defined according to new Lancet Commission diagnostic criteria, was estimated using ICD-10 codes corresponding to end-organ dysfunction.
Of 440 590 participants, 48.5% were female, 52% were aged 19-39 years and 37.1% were UAE nationals. 63.4% of the population were living with OAO. Significantly more UAE nationals (68.3%) were living with OAO than nationals from SEAR countries (59.7%, p < 0.001) or elsewhere (63.6%, respectively, p < 0.001). Significantly more females than males were living with obesity (30.4% vs. 25.9%, p < 0.001). About a half of female UAE nationals aged ≥40 years were living with obesity, about one in five of whom had class 2 or class 3 obesity. Using modified ethnicity-specific thresholds increased the overall proportion of people living with obesity in the UAE from 28.0% to 35.8%. About a third of individuals with a body mass index ≥40 kg/m also had signs or symptoms of ongoing organ dysfunction classifiable as clinical obesity.
This is the largest epidemiological study to provide direct prevalence data on OAO at this scale in the region and one of the largest globally. Using standard WHO cut points to define OAO may severely underestimate the prevalence of clinically actionable obesity in individuals of Southeast Asian ethnicity. This first application of new diagnostic criteria of clinical obesity suggests that some individuals may be disqualified from therapy who might otherwise benefit from a patient-centric approach.
尽管存在关于超重和肥胖（OAO）患病率的人群水平估计，但几乎没有大规模的直接OAO患病率流行病学调查。
这是一项横断面、多中心、基于人群的研究，研究对象为2018年1月至2023年8月期间就诊于迪拜学术健康集团（DAHC）的所有18岁以上成年人。OAO根据世界卫生组织（WHO）标准或针对来自WHO东南亚区域（SEAR）国家的个体的修改后的WHO切点进行定义。根据《柳叶刀》新委员会的诊断标准定义临床肥胖，使用与终末器官功能障碍相对应的ICD - 10编码进行估计。
在440590名参与者中，48.5%为女性，52%年龄在19 - 39岁之间，37.1%为阿联酋国民。63.4%的人群患有OAO。患有OAO的阿联酋国民（68.3%）明显多于来自SEAR国家的国民（59.7%，p < 0.001）或其他地区的国民（分别为63.6%，p < 0.001）。患有肥胖症的女性明显多于男性（30.4%对25.9%，p < 0.001）。年龄≥40岁的阿联酋女性国民中约有一半患有肥胖症，其中约五分之一患有2级或3级肥胖症。使用修改后的特定种族阈值使阿联酋肥胖人群的总体比例从28.0%提高到35.8%。体重指数≥40 kg/m²的个体中约有三分之一也有可归类为临床肥胖的持续器官功能障碍的体征或症状。
这是该地区规模最大的提供直接OAO患病率数据的流行病学研究，也是全球最大的此类研究之一。使用WHO标准切点来定义OAO可能会严重低估东南亚种族个体中临床上可采取行动的肥胖症患病率。临床肥胖新诊断标准的首次应用表明，一些个体可能不符合治疗条件，而他们原本可能会从以患者为中心
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