Paglione Heloisa Barboza, Escobosa Daisa de Mesquita, Pimenta Beatriz Mesquita, Della-Guardia Bianca, Boteon Amanda Pinter Carvalheiro da Silva, Boteon Yuri Longatto
Transplant Centre, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Health Economics Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2025 Apr 7;23:eAO0565. doi: 10.31744/einstein_journal/2025AO0565. eCollection 2025.
Liver transplantation significantly improves the health-related quality of life of patients with cirrhosis and high MELD scores. This study highlights rapid health-related quality of life gains after transplantation that were sustained during the one-year follow-up period, emphasizing the role of multidisciplinary care in achieving these outcomes.
To assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation.
This retrospective study analyzed HRQOL using the EQ-5D questionnaire before (T0), and 3 (T3), 6 (T6), and 12 (T12) months after, transplantation. The questionnaire comprised five health status scores, which were also combined into a single utility score. Changes in each dimension and in the utility score were examined.
A total of 212 patients were included in the study, with a mean age of 54 (SD, 12) years, and a median Model for End-Stage Liver Disease score of 17 (Q1= 11; Q3= 24). The most frequent etiology was chronic alcoholism (26.9%). Improvements in EQ-5D utility scores were registered at all post-transplantation time points compared to the score at T0: an increase of 0.22 points (p<0.001) at T3, 0.27 (p<0.001) at T6, and 0.268 (p<0.001) at T12. Scores increased over time in all domains of the EQ-5D.
In a large sample of high-risk transplant recipients, a significant improvement in HRQOL occurred three months after transplantation, and was sustained over the one-year follow-up period.
■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores.
■ Significant health-related quality of life improvements occur within three months of transplantation.
■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery.
■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation.
肝移植显著改善了肝硬化和终末期肝病模型（MELD）评分较高患者的健康相关生活质量。本研究强调了移植后健康相关生活质量的快速提升，并在一年的随访期内得以维持，强调了多学科护理在实现这些结果中的作用。
评估肝移植对等待移植的肝硬化患者健康相关生活质量的影响。
这项回顾性研究使用欧洲五维度健康量表（EQ-5D）问卷，在移植前（T0）、移植后3个月（T3）、6个月（T6）和12个月（T12）对健康相关生活质量（HRQOL）进行分析。该问卷包括五个健康状况评分，这些评分也合并为一个单一的效用评分。检查了每个维度和效用评分的变化。
共有212名患者纳入研究，平均年龄54（标准差12）岁，终末期肝病模型评分中位数为17（第一四分位数=11；第三四分位数=24）。最常见的病因是慢性酒精中毒（26.9%）。与T0时的评分相比，移植后所有时间点的EQ-5D效用评分均有所改善：T3时增加0.22分（p<0.001），T6时增加0.27分（p<0.001），T12时增加0.268分（p<0.001）。EQ-5D所有领域的评分均随时间增加。
在大量高风险移植受者样本中，移植后三个月健康相关生活质量显著改善，并在一年的随访期内得以维持。
■ 肝移植改善了肝硬化和高MELD评分患者的健康相关生活质量。
■ 移植后三个月内健康相关生活质量显著改善。
■ 多学科护理计划可促进肝移植后的身心恢复。
■ 持续的健康相关生活质量提升凸显了肝移植的长期益处。
