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本文引用的文献

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Evaluation of the impact of rehospitalization in the management of hepatic encephalopathy.再入院对肝性脑病管理影响的评估。
Int J Gen Med. 2015 May 5;8:165-73. doi: 10.2147/IJGM.S81878. eCollection 2015.
2
Model for End-stage Liver Disease.终末期肝病模型
J Clin Exp Hepatol. 2013 Mar;3(1):50-60. doi: 10.1016/j.jceh.2012.11.002. Epub 2012 Dec 1.
3
Quality of life in liver transplant candidates: frailty is a better indicator than severity of liver disease.肝移植候选者的生活质量：虚弱比肝脏疾病严重程度是更好的指标。
Transplantation. 2015 Feb;99(2):340-4. doi: 10.1097/TP.0000000000000593.
4
Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study.质子泵抑制剂治疗不会增加肝硬化自发性细菌性腹膜炎的发生率：一项多中心前瞻性研究。
J Hepatol. 2015 May;62(5):1056-60. doi: 10.1016/j.jhep.2014.11.036. Epub 2014 Dec 4.
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Soft and hard endpoints in acute variceal bleeding.急性静脉曲张出血的软性和硬性终点
Hepatology. 2015 Mar;61(3):762-5. doi: 10.1002/hep.27583. Epub 2015 Jan 28.
6
Predictors of quality of life in patients evaluated for liver transplantation.接受肝移植评估患者生活质量的预测因素。
Clin Transplant. 2014 Dec;28(12):1331-8. doi: 10.1111/ctr.12426. Epub 2014 Sep 27.
7
Renal dysfunction in end-stage liver disease and post-liver transplant.终末期肝病及肝移植后的肾功能障碍
Clin Liver Dis. 2014 Aug;18(3):543-60. doi: 10.1016/j.cld.2014.05.003.
8
Liver transplantation: a systematic review of long-term quality of life.肝移植：长期生活质量的系统评价
Liver Int. 2014 Oct;34(9):1298-313. doi: 10.1111/liv.12553. Epub 2014 Apr 23.
9
Health-related quality of life: two decades after liver transplantation.健康相关生活质量：肝移植二十年后。
Liver Transpl. 2014 Jun;20(6):649-54. doi: 10.1002/lt.23855.
10
Longitudinal study of liver transplant recipients' quality of life as a function of their perception of general health: at waiting list and at 3, 6, and 12 months post-transplantation.肝移植受者生活质量随其对总体健康感知的纵向研究：在等待名单时以及移植后3个月、6个月和12个月。
Transplant Proc. 2013;45(10):3653-5. doi: 10.1016/j.transproceed.2013.10.026.

低终末期肝病模型（MELD）评分的肝移植受者及等待名单上患者的健康相关生活质量和情感状况

Health-related quality of life and affective status in liver transplant recipients and patients on the waiting list with low MELD scores.

作者信息

Benzing Christian, Krezdorn Nicco, Förster Julia, Hinz Andreas, Krenzien Felix, Atanasov Georgi, Schmelzle Moritz, Hau Hans-Michael, Bartels Michael

机构信息

Department of General, Visceral and Transplantation Surgery, Campus Virchow, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of General, Visceral, Thoracic and Vascular Surgery, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.

Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neubergstr. 1, 30625 Hannover, Germany.

出版信息

HPB (Oxford). 2016 May;18(5):449-55. doi: 10.1016/j.hpb.2016.01.546. Epub 2016 Apr 20.

DOI:10.1016/j.hpb.2016.01.546
PMID:27154809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4857066/
Abstract

BACKGROUND

This study seeks to examine the impact of orthotopic liver transplantation (OLT) on Health-Related Quality of Life (HRQoL) and mental health in patients with different MELD scores.

METHODS

Patients who has undergone orthotopic liver transplant (OLT) or were on the waiting list for OLT were submitted to HRQoL and depression/anxiety assessment by questionnaire: Short-Form 36 (SF-36), Questions on Life Satisfaction (FLZ-M), Patient Health Questionnaire-4 (PHQ-4). Data were analysed following division of patients into three groups: pretransplant patients with a MELD score <10, ≥10, and OLT recipients.

RESULTS

The surveys were sent to 940 consecutive patients within one week in June 2013. Of these 940 patients, 869 (92.4%) met the inclusion criteria. In total, 291 (33.5%) eligible questionnaires (OLT group: 235, MELD <10: 25; MELD _10: 31) were suitable for analysis. General health (GH), vitality (VIT), and mental health (MH) were lower in both pretransplant groups compared to the OLT group (all p < 0.05). Anxiety and depression were higher in the MELD <10 group than in the OLT group (anxiety: p < 0.05; depression: p < 0.01).

DISCUSSION

Patients with low MELD scores seem to benefit from OLT with regards to HRQoL and mental health.

摘要

背景

本研究旨在探讨原位肝移植（OLT）对不同终末期肝病模型（MELD）评分患者的健康相关生活质量（HRQoL）和心理健康的影响。

方法

对接受原位肝移植（OLT）或在OLT等待名单上的患者进行问卷调查，以评估HRQoL和抑郁/焦虑情况：简短健康调查问卷（SF-36）、生活满意度问卷（FLZ-M）、患者健康问卷-4（PHQ-4）。将患者分为三组进行数据分析：MELD评分<10的移植前患者、MELD评分≥10的移植前患者和OLT受者。

结果

2013年6月的一周内，连续向940例患者发送了调查问卷。在这940例患者中，869例（92.4%）符合纳入标准。总共291份（33.5%）合格问卷（OLT组：235份，MELD<10组：25份；MELD_10组：31份）适合分析。与OLT组相比，两个移植前组的总体健康（GH）、活力（VIT）和心理健康（MH）较低（所有p<0.05）。MELD<10组的焦虑和抑郁水平高于OLT组（焦虑：p<0.05；抑郁：p<0.01）。

讨论

低MELD评分的患者似乎在HRQoL和心理健康方面从OLT中获益。