低终末期肝病模型（MELD）评分的肝移植受者及等待名单上患者的健康相关生活质量和情感状况
Health-related quality of life and affective status in liver transplant recipients and patients on the waiting list with low MELD scores.
作者信息
Benzing Christian, Krezdorn Nicco, Förster Julia, Hinz Andreas, Krenzien Felix, Atanasov Georgi, Schmelzle Moritz, Hau Hans-Michael, Bartels Michael
机构信息
Department of General, Visceral and Transplantation Surgery, Campus Virchow, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of General, Visceral, Thoracic and Vascular Surgery, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neubergstr. 1, 30625 Hannover, Germany.
出版信息
HPB (Oxford). 2016 May;18(5):449-55. doi: 10.1016/j.hpb.2016.01.546. Epub 2016 Apr 20.
BACKGROUND
This study seeks to examine the impact of orthotopic liver transplantation (OLT) on Health-Related Quality of Life (HRQoL) and mental health in patients with different MELD scores.
METHODS
Patients who has undergone orthotopic liver transplant (OLT) or were on the waiting list for OLT were submitted to HRQoL and depression/anxiety assessment by questionnaire: Short-Form 36 (SF-36), Questions on Life Satisfaction (FLZ-M), Patient Health Questionnaire-4 (PHQ-4). Data were analysed following division of patients into three groups: pretransplant patients with a MELD score <10, ≥10, and OLT recipients.
RESULTS
The surveys were sent to 940 consecutive patients within one week in June 2013. Of these 940 patients, 869 (92.4%) met the inclusion criteria. In total, 291 (33.5%) eligible questionnaires (OLT group: 235, MELD <10: 25; MELD _10: 31) were suitable for analysis. General health (GH), vitality (VIT), and mental health (MH) were lower in both pretransplant groups compared to the OLT group (all p < 0.05). Anxiety and depression were higher in the MELD <10 group than in the OLT group (anxiety: p < 0.05; depression: p < 0.01).
DISCUSSION
Patients with low MELD scores seem to benefit from OLT with regards to HRQoL and mental health.
背景
本研究旨在探讨原位肝移植（OLT）对不同终末期肝病模型（MELD）评分患者的健康相关生活质量（HRQoL）和心理健康的影响。
方法
对接受原位肝移植（OLT）或在OLT等待名单上的患者进行问卷调查，以评估HRQoL和抑郁/焦虑情况：简短健康调查问卷（SF-36）、生活满意度问卷（FLZ-M）、患者健康问卷-4（PHQ-4）。将患者分为三组进行数据分析：MELD评分<10的移植前患者、MELD评分≥10的移植前患者和OLT受者。
结果
2013年6月的一周内，连续向940例患者发送了调查问卷。在这940例患者中，869例（92.4%）符合纳入标准。总共291份（33.5%）合格问卷（OLT组：235份，MELD<10组：25份；MELD_10组：31份）适合分析。与OLT组相比，两个移植前组的总体健康（GH）、活力（VIT）和心理健康（MH）较低（所有p<0.05）。MELD<10组的焦虑和抑郁水平高于OLT组（焦虑：p<0.05；抑郁：p<0.01）。
讨论
低MELD评分的患者似乎在HRQoL和心理健康方面从OLT中获益。
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