囊性纤维化中妥布霉素的剂量——一篇简短报告。
Dosage of tobramycin in cystic fibrosis--a short report.
作者信息
Chrystyn H, Alexander J M
出版信息
J Clin Hosp Pharm. 1985 Jun;10(2):219-20. doi: 10.1111/j.1365-2710.1985.tb01136.x.
Abstract
A 15 kg, 7-year-old girl with cystic fibrosis was admitted with a chest infection. It was found that a tobramycin, 12 mg/kg/day (standard recommended dose 6-7.5 mg/kg/day), was required to obtain acceptable plasma levels and that the volume of distribution varied in line with the patient's weight changes.
摘要
一名15公斤重、7岁的患有囊性纤维化的女孩因胸部感染入院。发现需要使用妥布霉素，剂量为12毫克/公斤/天（标准推荐剂量为6 - 7.5毫克/公斤/天）才能达到可接受的血浆水平，且分布容积随患者体重变化而变化。
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