Geller B, Cooper T B, Chestnut E C
J Clin Psychopharmacol. 1985 Aug;5(4):213-6.
Children and adolescents 6 to 16 years old (N = 25), who were diagnosed as having major depressive disorder, received a fixed daily dose of nortriptyline during an 8-week period. Nortriptyline plasma levels were drawn and assayed weekly. Data were analyzed for the total sample (N = 25) and separately for the subgroup of 6 to 9 year olds (N = 9) and for the subsample of 10 to 16 year olds (N = 16). There were no significant differences between the day 7 (week 1) plasma levels and the means of weeks 2 to 8 or between the means of weeks 1 to 4 and 5 to 8 within the total sample or within either subgroup. These findings suggest that nortriptyline steady state plasma levels within the pediatric age range are achieved by day 7 (week 1) and that nortriptyline (during the pediatric years) does not induce its own metabolism during an 8-week period. The achievement of steady state by day 7 is similar to that found in adults. The mean coefficients of variation were calculated for the total sample and for each subsample and were 13.7 +/- 4.0% (range, 8 to 20%) for the 6 to 9 year olds; 13.8 +/- 3.2% (range, 10 to 21%) for the 10 to 16 year olds; and 13.8 +/- 3.4% (range, 8 to 21%) for the total sample. These coefficients of variation are similar to the 10 to 20% range reported in adult subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
6至16岁被诊断患有重度抑郁症的儿童和青少年（N = 25），在8周期间每日服用固定剂量的去甲替林。每周采集并检测去甲替林血浆水平。对总样本（N = 25）进行数据分析，并分别对6至9岁亚组（N = 9）和10至16岁亚样本（N = 16）进行分析。在总样本或任何一个亚组中，第7天（第1周）的血浆水平与第2至8周的平均值之间，以及第1至4周和第5至8周的平均值之间均无显著差异。这些发现表明，在儿科年龄范围内，去甲替林在第7天（第1周）达到稳态血浆水平，并且去甲替林（在儿童期）在8周期间不会诱导自身代谢。第7天达到稳态的情况与在成人中发现的情况相似。计算了总样本和每个亚样本的平均变异系数，6至9岁儿童为13.7 +/- 4.0%（范围8至20%）；10至16岁儿童为13.8 +/- 3.2%（范围10至21%）；总样本为13.8 +/- 3.4%（范围8至21%）。这些变异系数与在成年受试者中报告的10至20%范围相似。（摘要截短为250字）
