Geller B, Cooper T B, Schluchter M D, Warham J E, Carr L G
Childhood Affective Disorders Program, William S. Hall Psychiatric Institute, Columbia, South Carolina 29202.
J Clin Psychopharmacol. 1987 Oct;7(5):321-3.
This is the final report of a study of single dose pharmacokinetic parameters of nortriptyline in children and adolescents 5 to 16 years old (N = 64). The data were analyzed separately for the 5- to 12-year-olds (N = 41) and for the 13- to 16-year-olds (N = 32). The results confirm the preliminary findings of the similarity of the pharmacology of nortriptyline between the pediatric and adult age groups with respect to a logarithmically linear rate of elimination and a wide interindividual rate of metabolism. The 5- to 12-year-olds had a significantly shorter mean half-life and a significantly greater mean apparent oral clearance than the 13- to 16-year-olds. The mean half-life in the 5- to 12-year-olds was 20.8 +/- 7.2 (range, 11.2 to 42.5) hours and in the 13- to 16-year-olds was 31.1 +/- 19.8 (range, 14.2 to 89.4) hours. A twice a day dosage regimen is recommended for the entire 5- to 16-year-old group based on their range of half-lives.
这是一项关于5至16岁儿童及青少年（N = 64）去甲替林单剂量药代动力学参数研究的最终报告。数据分别针对5至12岁儿童（N = 41）和13至16岁青少年（N = 32）进行分析。结果证实了先前的研究发现，即去甲替林在儿科和成人年龄组中的药理学在消除对数线性速率和广泛的个体间代谢速率方面具有相似性。5至12岁儿童的平均半衰期显著短于13至16岁青少年，平均表观口服清除率则显著高于后者。5至12岁儿童的平均半衰期为20.8 +/- 7.2（范围为11.2至42.5）小时，13至16岁青少年的平均半衰期为31.1 +/- 19.8（范围为14.2至89.4）小时。基于5至16岁儿童群体的半衰期范围，建议采用每日两次的给药方案。
