Drury J K, Yamazaki S, Fishbein M C, Meerbaum S, Corday E
J Am Coll Cardiol. 1985 Aug;6(2):328-35. doi: 10.1016/s0735-1097(85)80168-6.
The safety and efficacy of a new clinical synchronized diastolic retroperfusion mechanical pump and autoinflatable balloon catheter was studied in 10 dogs during and after 6 hours of left anterior descending coronary artery occlusion. Eight other dogs served as the untreated control group. Infarct size measured by triphenyltetrazolium chloride, and expressed as a percent of area at risk, was significantly reduced by retroperfusion treatment (19 +/- 18 versus 58 +/- 36, p less than 0.01). Morphologic examination of the coronary sinus and cardiac veins did not demonstrate evidence of damage from synchronized retroperfusion. There was also no evidence of excess myocardial edema in either the jeopardized ischemic or normally perfused zones. There was no evidence of significant red cell hemolysis or platelet destruction from the treatment. Thus, it appears that synchronized diastolic retroperfusion is a safe and effective treatment of acute myocardial ischemia in experimental animals and warrants clinical testing.
在10只犬的左前降支冠状动脉闭塞6小时期间及之后，对一种新型临床同步舒张期逆向灌注机械泵和自动充气球囊导管的安全性和有效性进行了研究。另外8只犬作为未治疗的对照组。通过氯化三苯基四氮唑测量的梗死面积，以危险区域面积的百分比表示，逆向灌注治疗使其显著降低（19±18对58±36，p＜0.01）。对冠状窦和心静脉的形态学检查未显示同步逆向灌注造成损伤的证据。在濒危缺血区或正常灌注区也没有心肌水肿过多的证据。治疗未出现明显红细胞溶血或血小板破坏的证据。因此，同步舒张期逆向灌注似乎是实验动物急性心肌缺血的一种安全有效的治疗方法，值得进行临床试验。
