Mattoli S, Rosati G, Mormile F, Ciappi G
J Allergy Clin Immunol. 1985 Aug;76(2 Pt 1):214-22. doi: 10.1016/0091-6749(85)90704-3.
We investigated the immediate effect of corticosteroids on pulmonary function (FEV1 and forced expiratory flow measured between 25% and 75% of vital capacity) and methacholine airway reactivity during a period of 8 hours after an intravenous bolus of 6-methyl-prednisolone (1 mg/kg) or saline placebo administered in a double-blind, crossover schedule in 12 patients with well-controlled asthma. The short-term effect of corticosteroids was also studied with bronchial reactivity to methacholine and pulmonary function measured before and at the end of 8 days of 6-methyl-prednisolone therapy (32 mg once a day, orally) in a group of six treated subjects as well as in a control group. There were no immediate or short-term effects from 6-methyl-prednisolone on bronchial response to inhaled methacholine. After 8 days of corticosteroid administration, forced expiratory flow measured between 25% and 75% of vital capacity significantly increased in the treated group (p less than 0.025). We concluded that "primary hyperreactivity" appears to be insensitive to an intravenous bolus or 8 days of treatment with oral corticosteroids and that the improvement in respiratory function is slight and slowly evolving in subjects with well-controlled asthma.
我们采用双盲、交叉方案，对12例病情控制良好的哮喘患者静脉推注6-甲基泼尼松龙（1毫克/千克）或生理盐水安慰剂后8小时内，研究了皮质类固醇对肺功能（第一秒用力呼气容积以及肺活量25%至75%之间的用力呼气流量）和乙酰甲胆碱气道反应性的即时影响。我们还在一组6例接受治疗的受试者以及一个对照组中，研究了6-甲基泼尼松龙治疗8天（每天口服32毫克）前后，皮质类固醇对乙酰甲胆碱支气管反应性和肺功能的短期影响。6-甲基泼尼松龙对吸入乙酰甲胆碱的支气管反应没有即时或短期影响。皮质类固醇给药8天后，治疗组肺活量25%至75%之间的用力呼气流量显著增加（p小于0.025）。我们得出结论，“原发性高反应性”似乎对静脉推注或口服皮质类固醇8天治疗不敏感，并且在病情控制良好的哮喘患者中，呼吸功能的改善轻微且进展缓慢。
