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We investigated the effect of 2 weeks therapy with oral cetirizine (10 mg twice daily) on methacholine bronchial reactivity in 14 asthmatics. All had bronchial hyperreactivity to methacholine on entry to the study, with a geometric mean cumulative PC20 of 0.83 mg ml-1 (range 0.1-3.61 mg ml-1) and eight were atopic on skin prick testing. 2. The study was placebo-controlled and in randomised order, with a minimum 1 month washout period between cetirizine and placebo study periods. Four methacholine challenges were performed in all, at the beginning and at the end of each study period. 3. No significant change in methacholine reactivity was found following 2 weeks therapy with cetrizine. The repeatability coefficient for the PC20 methacholine over 2 weeks was found to be 2.90 doubling dilutions for the placebo period and 1.73 doubling dilutions for the cetirizine period. The study had a 80% power at the 5% significance level (two-tailed) to detect a 1.16-doubling concentration change in methacholine reactivity. 4. We conclude that 2 weeks therapy with cetirizine has no significant effect on non-specific bronchial hyperreactivity.

我们研究了口服西替利嗪（10毫克，每日两次）治疗两周对14名哮喘患者乙酰甲胆碱支气管反应性的影响。所有患者在进入研究时对乙酰甲胆碱均有支气管高反应性，几何平均累积PC20为0.83毫克/毫升（范围为0.1 - 3.61毫克/毫升），8名患者皮肤点刺试验呈特应性。
该研究为安慰剂对照且随机分组，在西替利嗪和安慰剂研究期之间有至少1个月的洗脱期。总共在每个研究期开始和结束时进行了四次乙酰甲胆碱激发试验。
西替利嗪治疗两周后，乙酰甲胆碱反应性未发现显著变化。发现安慰剂期PC20乙酰甲胆碱在两周内的重复性系数为2.90倍稀释，西替利嗪期为1.73倍稀释。该研究在5%显著性水平（双侧）下有80%的检验效能来检测乙酰甲胆碱反应性1.16倍浓度变化。
我们得出结论，西替利嗪治疗两周对非特异性支气管高反应性无显著影响。

We investigated the effect of 2 weeks therapy with oral cetirizine (10 mg twice daily) on methacholine bronchial reactivity in 14 asthmatics. All had bronchial hyperreactivity to methacholine on entry to the study, with a geometric mean cumulative PC20 of 0.83 mg ml-1 (range 0.1-3.61 mg ml-1) and eight were atopic on skin prick testing. 2. The study was placebo-controlled and in randomised order, with a minimum 1 month washout period between cetirizine and placebo study periods. Four methacholine challenges were performed in all, at the beginning and at the end of each study period. 3. No significant change in methacholine reactivity was found following 2 weeks therapy with cetrizine. The repeatability coefficient for the PC20 methacholine over 2 weeks was found to be 2.90 doubling dilutions for the placebo period and 1.73 doubling dilutions for the cetirizine period. The study had a 80% power at the 5% significance level (two-tailed) to detect a 1.16-doubling concentration change in methacholine reactivity. 4. We conclude that 2 weeks therapy with cetirizine has no significant effect on non-specific bronchial hyperreactivity.

我们研究了口服西替利嗪（10毫克，每日两次）治疗两周对14名哮喘患者乙酰甲胆碱支气管反应性的影响。所有患者在进入研究时对乙酰甲胆碱均有支气管高反应性，几何平均累积PC20为0.83毫克/毫升（范围为0.1 - 3.61毫克/毫升），8名患者皮肤点刺试验呈特应性。
该研究为安慰剂对照且随机分组，在西替利嗪和安慰剂研究期之间有至少1个月的洗脱期。总共在每个研究期开始和结束时进行了四次乙酰甲胆碱激发试验。
西替利嗪治疗两周后，乙酰甲胆碱反应性未发现显著变化。发现安慰剂期PC20乙酰甲胆碱在两周内的重复性系数为2.90倍稀释，西替利嗪期为1.73倍稀释。该研究在5%显著性水平（双侧）下有80%的检验效能来检测乙酰甲胆碱反应性1.16倍浓度变化。
我们得出结论，西替利嗪治疗两周对非特异性支气管高反应性无显著影响。

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