Dhuppar Shivnarayan, Poller Wolfram C, Murugaiyan Gopal
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.
Trends Mol Med. 2025 Apr 7. doi: 10.1016/j.molmed.2025.03.006.
A combination of intracellular and extracellular abnormalities of the nervous system, coupled with inflammation and intestinal dysbiosis, form the hallmarks of neurodegenerative diseases (NDDs). While it is difficult to identify the precise order in which these hallmarks manifest in NDDs because of their mutualistic nature, they cumulatively result in nervous or neuronal damage that characterizes neurodegeneration. In this review we discuss the roles of microRNAs (miRNAs) in the maintenance of nervous system homeostasis and their implication for NDDs. We further highlight recent advances in, and limitations of, miRNA therapeutics in NDDs and their future potential.
神经系统细胞内和细胞外异常，再加上炎症和肠道微生物群失调，构成了神经退行性疾病（NDDs）的特征。由于这些特征之间相互依存的性质，很难确定它们在NDDs中出现的确切顺序，但它们共同导致了神经或神经元损伤，这是神经退行性变的特征。在这篇综述中，我们讨论了微小RNA（miRNA）在维持神经系统稳态中的作用及其与NDDs的关联。我们还强调了miRNA疗法在NDDs中的最新进展、局限性及其未来潜力。
