Smits-Engelsman Bouwien, Duysens Jacques
Physical Activity, Sport and Recreation, Faculty Health Sciences, North-West University, Potchefstroom, South Africa.
Motor Control Laboratory, Movement Control and Neuroplasticity Research Group KU Leuven, Leuven, Belgium.
Sci Rep. 2025 Apr 8;15(1):12035. doi: 10.1038/s41598-025-96594-3.
Clinicians require quantitative measures of functional movement to inform care decisions for persons with Parkinson's disease (PWPs). To address this need, we developed the Parkinson's Disease-Functional Movement Battery (PD-FUNC), which includes valid items from existing assessments and evaluates five key areas from the MDS-UPDRS-III: manual dexterity, functional strength, locomotion, static balance, and activities of daily living. This study assessed the PD-FUNC's ability to distinguish between PWPs and healthy controls based on effect sizes and analyzed differences according to disease progression using years since diagnosis and MDS-UPDRS-III scores, as well as Hoehn & Yahr (H&Y) stages. The test was administered to 81 PD patients (H&Y stages 1-3) and 81 age-matched controls. All items, except grip force, discriminated effectively, with dexterity tasks showing the highest sensitivity (effect size r = 0.52-0.63). The PD-FUNC distinguished PD stages well, revealing early symptoms through dexterity tests (p = 0.001) and late-stage symptoms via dynamic stability tests. The PD-FUNC could provide a comprehensive assessment within 30-40 min and could be used to evaluate disease progression and medication effectiveness at home and in clinical settings.
临床医生需要功能性运动的定量测量方法，以便为帕金森病患者（PWPs）的护理决策提供依据。为满足这一需求，我们开发了帕金森病-功能性运动组合测试（PD-FUNC），它包含了现有评估中的有效项目，并从MDS-UPDRS-III评估五个关键领域：手部灵活性、功能强度、运动能力、静态平衡和日常生活活动。本研究基于效应量评估了PD-FUNC区分帕金森病患者和健康对照的能力，并根据疾病进展情况，使用诊断后的年限、MDS-UPDRS-III评分以及霍恩和雅尔（H&Y）分期分析差异。该测试对81名帕金森病患者（H&Y分期1-3期）和81名年龄匹配的对照者进行了施测。除握力外，所有项目均能有效区分，手部灵活性任务显示出最高的敏感性（效应量r = 0.52-0.63）。PD-FUNC能很好地区分帕金森病的不同阶段，通过手部灵活性测试揭示早期症状（p = 0.001），通过动态稳定性测试揭示晚期症状。PD-FUNC可以在30-40分钟内提供全面评估，可用于在家中和临床环境中评估疾病进展和药物疗效。
