Hu Xu, Pan Ling, Fu Chunchan, Zhu Qing, Hao Jiangshan, Wang Xiaochun, Nawaz Mohsin, Qu Jia, Zhang Jinlin, Chen Yu, Zong Junqin, Liao Li, Tang Minqiang, Wang Zhiyong
College of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Sanya, 572000, China.
School of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, China.
BMC Plant Biol. 2025 Apr 8;25(1):441. doi: 10.1186/s12870-025-06478-x.
Cadmium (Cd) pollution in the farmland has become a serious global issue threatening both human health and plant biomass production. Seashore paspalum (Paspalum vaginatum Sw.), a halophytic turfgrass, has been recognized as a Cd-tolerant species. However, the underlying genetic basis of natural variations in Cd tolerance still remains unknown. This study is possibly the first to apply genome-wide association studies (GWAS) and selective sweep analysis to identify potential Cd stress-responsive genes in P. vaginatum. We identified a total of 89 candidate genes and 656 putative selective sweeps regions. Based on the correlation analysis of differentially expressed metabolites (DEMs) and differentially expressed genes (DEGs), we identified the 55 key genes associated with metabolic changes induced by Cd treatment as the Cd tolerance-related genes. These genes showed significantly higher expression in Cd-tolerant accessions as compared to Cd-susceptive accessions. Therefore, our multi-omics study revealed the molecular and genetic basis of Cd tolerance, which may help develop Cd tolerant crop varieties.
农田中的镉（Cd）污染已成为一个严重的全球性问题，威胁着人类健康和植物生物量生产。海滨雀稗（Paspalum vaginatum Sw.）是一种盐生草坪草，已被认为是一种耐镉物种。然而，镉耐受性自然变异的潜在遗传基础仍然未知。本研究可能是首次应用全基因组关联研究（GWAS）和选择性清除分析来鉴定海滨雀稗中潜在的镉胁迫响应基因。我们共鉴定出89个候选基因和656个推定的选择性清除区域。基于差异表达代谢物（DEM）和差异表达基因（DEG）的相关性分析，我们将与镉处理诱导的代谢变化相关的55个关键基因鉴定为耐镉相关基因。与镉敏感材料相比，这些基因在耐镉材料中表现出显著更高的表达。因此，我们的多组学研究揭示了镉耐受性的分子和遗传基础，这可能有助于培育耐镉作物品种。
