用于治疗方法的癌细胞焦亡调控：挑战与机遇

Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities.

作者信息

Miao Rui, Wang Xueying, Zhang Jingyv, Kang Qinyv, Liu Qing, Luo Xianglin, Hou Junwei, Gao Baorong

机构信息

Department of Otolaryngology Head and Neck Surgery, Central South University, Xiangya Road 87, Changsha, Hunan, 410008, China.

Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Xiangya Road 87, Changsha, Hunan, 410008, China.

出版信息

Biomark Res. 2025 Apr 9;13(1):58. doi: 10.1186/s40364-025-00771-5.

DOI:10.1186/s40364-025-00771-5

PMID:40200299

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11980353/

Abstract

Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible. Besides immune cells, pyroptosis has also been observed in cancer cells, which exhibit distinct mechanisms compared to canonical immune cell pyroptosis. Although chronic cancer cell pyroptosis fuels tumor growth, intense pyroptotic cell death in tumor cells enhances anticancer immunity by promoting killer lymphocytes infiltration. Triggering pyroptosis in cancer cells is emerging as a promising strategy for cancer treatment. In this review, we introduce the process of cancer cell pyroptosis and its role in antitumor immunity, discuss the translation of these insights into therapies, and highlight current challenges and opportunities in the investigation of cancer cell pyroptosis.

摘要

在发现gasdermins是细胞焦亡的执行者之后，已经取得了显著进展。细胞焦亡过程包括亚细胞通透性增加阶段和细胞裂解阶段，后者是不可逆的。除了免疫细胞外，癌细胞中也观察到细胞焦亡，与经典免疫细胞焦亡相比，其机制有所不同。虽然慢性癌细胞焦亡会促进肿瘤生长，但肿瘤细胞中强烈的细胞焦亡性死亡通过促进杀伤性淋巴细胞浸润增强抗癌免疫力。触发癌细胞中的细胞焦亡正在成为一种有前景的癌症治疗策略。在这篇综述中，我们介绍了癌细胞焦亡的过程及其在抗肿瘤免疫中的作用，讨论了将这些见解转化为治疗方法的情况，并强调了当前癌细胞焦亡研究中的挑战和机遇。