Werner Liliana, Kelkar Neil, Eid Kevin, Ricks Reiker G, Ungricht Emilie L, Pettey Jeff H
From the Intermountain Ocular Research Center, Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
J Cataract Refract Surg. 2025 Apr 9. doi: 10.1097/j.jcrs.0000000000001668.
To quantify damage to corneal endothelial cells (CECs) from a new handheld lens fragmentation device and compare it with damage from a standard phacoemulsification device.
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
Experimental Study.
Fifteen New Zealand white rabbits received bilateral surgery. Their eyes were divided into 3 groups (10 eyes/group): Intrepid Balanced Tip (Centurion Ozil handpiece; Alcon), miCOR 700 (Zeiss) half throttle (infusion/aspiration only), or full throttle (lens agitator engaged). After incision, the tip of each device was inserted into the anterior chamber and activated for 30 seconds. Following euthanasia and enucleation, the corneas were removed, stained with trypan blue/alizarin red, and photographed in a standardized manner (five X400 magnification photos from the center of each cornea). The ImageJ program was used to evaluate CEC damage and loss in the photographs.
The overall differences among the 3 groups regarding intact, damaged, and lost cells were statistically significant. However, by applying the Bonferroni correction, only the post-hoc pairwise comparisons between groups 1 (phaco tip) and 2 (miCOR tip, half throttle, without lens agitator engaged) were statistically significant regarding the 3 above-mentioned parameters.Conclusion: miCOR is a handheld, finger-controlled lens removal device with a blunt and rounded tip that vibrates at a low frequency, using mechanical agitation for nuclear disassembly. This acute rabbit study suggests CEC damage from the device, when the lens agitator is engaged is comparable to that of standard torsional phacoemulsification.
量化一种新型手持晶状体破碎装置对角膜内皮细胞（CEC）的损伤，并将其与标准超声乳化装置造成的损伤进行比较。
美国犹他州盐湖城犹他大学约翰·A·莫兰眼科中心。
实验研究。
15只新西兰白兔接受双侧手术。它们的眼睛被分为3组（每组10只眼）：Intrepid平衡头（Centurion Ozil手持件；爱尔康）、miCOR 700（蔡司）半油门（仅灌注/抽吸）或全油门（晶状体搅拌器启动）。切口后，将每个装置的尖端插入前房并启动30秒。安乐死和眼球摘除后，取出角膜，用台盼蓝/茜素红染色，并以标准化方式拍照（从每个角膜中心拍摄五张放大400倍的照片）。使用ImageJ程序评估照片中CEC的损伤和损失。
3组在完整细胞、受损细胞和丢失细胞方面的总体差异具有统计学意义。然而，通过应用Bonferroni校正，仅在上述3个参数方面，第1组（超声乳化头）和第2组（miCOR头，半油门，未启动晶状体搅拌器）之间的事后两两比较具有统计学意义。
miCOR是一种手持、手指控制的晶状体摘除装置，尖端钝圆，低频振动，利用机械搅拌进行核分解。这项急性兔研究表明，当启动晶状体搅拌器时，该装置对CEC的损伤与标准扭转超声乳化相当。
