Bättig Linda, Kissling Francis, Motov Stefan, Stengel Felix C, Yildiz Yesim, Feuerstein Laurin, Fischer Gregor, Schöfl Thomas, Gianoli Daniele, Hejrati Nader, Martens Benjamin, Stienen Martin N, Bertulli Lorenzo
Spine Center of Eastern Switzerland, Cantonal Hospital of St. Gallen & Medical School of St. Gallen, St. Gallen, Switzerland.
Department of Neurosurgery, Cantonal Hospital of St. Gallen & Medical School of St. Gallen, St. Gallen, Switzerland.
Global Spine J. 2025 Apr 8:21925682251332547. doi: 10.1177/21925682251332547.
Study DesignRetrospective cohort study.ObjectivesTo evaluate the frequency, risk factors, and impact of incidental durotomy on adverse events and outcomes after TLIF with expandable interbody spacers.MethodsWe reviewed 433 consecutive patients treated by TLIF using expandable titanium interbody implants (ALTERA®, Globus Medical Inc) on 538 levels between December 2018 and September 2023. Patients with incidental durotomy (ID) and cerebrospinal fluid leakage were compared to patients without ID, focusing on patient-specific and surgery-related factors, adverse events, clinical outcomes (MacNab criteria), and radiological outcomes at discharge, 3, and 12 months.ResultsThe ID rate was 9.0% (39/433 patients). Patients with ID had lower BMI (26.1 ± 5.2 vs 28.0 ± 5.3 kg/m, = .03), longer surgery duration (358 ± 132 vs 305 ± 128 minutes, = .01), and extended hospital stays (14.7 ± 12.8 vs 10.9 ± 8.2 days, < .01). More postoperative adverse events (51.3% vs 28.7%, = .004) with higher severity (28.2% vs 13.2% moderate to severe, = .019) occurred at discharge. No differences were found in outcomes at 3 or 12 months. ID patients showed higher risks for impaired wound healing (adjusted OR, 4.39; 95% CI, 1.90-10.2; = .001) and pulmonary embolism (adjusted OR, 3.52; 95% CI, 1.13-10.9; = .029).ConclusionsIncidental durotomy was associated with longer surgery time, hospital stays, and increased early postoperative complications. While not affecting mid-to-long-term outcomes, ID increased risks for wound healing difficulties and pulmonary embolisms.
研究设计
回顾性队列研究。
目的
评估在使用可扩张椎间融合器的经椎间孔腰椎椎间融合术(TLIF)中,意外硬脊膜切开术的发生率、危险因素及其对不良事件和手术结局的影响。
方法
我们回顾了2018年12月至2023年9月期间连续接受使用可扩张钛制椎间融合器(ALTERA®,Globus Medical Inc)进行TLIF治疗的433例患者,共538个节段。将发生意外硬脊膜切开术(ID)和脑脊液漏的患者与未发生ID的患者进行比较,重点关注患者特异性因素和手术相关因素、不良事件、临床结局(MacNab标准)以及出院时、3个月和12个月时的影像学结局。
结果
ID发生率为9.0%(39/433例患者)。发生ID的患者体重指数较低(26.1±5.2 vs 28.0±5.3kg/m²,P = 0.03),手术时间较长(358±132 vs 305±128分钟,P = 0.01),住院时间延长(14.7±12.8 vs 10.9±8.2天,P < 0.01)。出院时发生更多术后不良事件(51.3% vs 28.7%,P = 0.004),且严重程度更高(28.2% vs 13.2%为中度至重度,P = 0.019)。在3个月或12个月时的结局方面未发现差异。ID患者伤口愈合受损风险较高(调整后比值比,4.39;95%置信区间,1.90 - 10.2;P = 0.001)和肺栓塞风险较高(调整后比值比,3.52;95%置信区间,1.13 - 10.9;P = 0.029)。
结论
意外硬脊膜切开术与手术时间延长、住院时间延长以及术后早期并发症增加相关。虽然不影响中长期结局,但ID增加了伤口愈合困难和肺栓塞的风险。