2型糖尿病影响梅毒治疗效果且是晚期梅毒的一个危险因素：一项回顾性队列研究
Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study.
作者信息
Tang Yijie, Wu Mengxiao, Xu Wenwen, Yu Jiajie, Yang Dandan, Zhang Jiaqin, Shen Lingyun, Xie Qinghui, Luo Qingqiong
机构信息
Department of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Biochemistry, School of Basic medical science, Fudan University, Shanghai, China.
出版信息
Acta Derm Venereol. 2025 Apr 8;105:adv42210. doi: 10.2340/actadv.v105.42210.
This study examined the relationship between type 2 diabetes and late syphilis. A retrospective analysis was conducted, including 96 syphilis patients with type 2 diabetes and 122 matched non-diabetic syphilis controls. The development of late-stage syphilis and responses to initial treatment were monitored over a 2-year period. Stratified logistic regression was used to assess whether diabetes increased the risk of late syphilis. Differences in initial treatment responses between the 2 groups were evaluated using χ2 tests and Kaplan-Meier curves. The cohort study confirmed that the serological cure rate within 12 months was significantly lower in diabetic syphilis patients. Type 2 diabetes significantly impacts the efficacy of syphilis treatment and is a risk factor for late syphilis.
本研究探讨了2型糖尿病与晚期梅毒之间的关系。进行了一项回顾性分析，纳入了96例患有2型糖尿病的梅毒患者和122例匹配的非糖尿病梅毒对照。在2年期间监测晚期梅毒的发生情况以及对初始治疗的反应。采用分层逻辑回归评估糖尿病是否增加晚期梅毒的风险。使用χ2检验和Kaplan-Meier曲线评估两组之间初始治疗反应的差异。队列研究证实，糖尿病梅毒患者12个月内的血清学治愈率显著较低。2型糖尿病显著影响梅毒治疗的疗效，是晚期梅毒的一个危险因素。
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