Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
Shenzhen Pingshan Maternal and Child Health Hospital, Shenzhen, China.
PLoS One. 2021 Jan 28;16(1):e0245812. doi: 10.1371/journal.pone.0245812. eCollection 2021.
Syphilis is a common infectious disease worldwide. Serological monitoring is important for syphilis management. We currently know little about the characteristics of this seronegative response. The aim of this study was to explore the factors associated with serological cure after treatment of early syphilis.
A retrospective cohort study was conducted and the data of patients with early syphilis in a clinic in Shenzhen from 2011 to 2019 were retrieved. Univariable and multiple Cox proportional hazard regression models were utilized to identify factors associated with a serological cure state among syphilis patients with early syphilis two years after treatment.
A total of 346 (85.9%) syphilis patients achieved serological cure. The multivariate analysis results revealed that having a baseline TRUST titer >1:8 was associated with an increased probability of serological cure, compared with having a baseline TRUST titer ≤1:8 (HR = 1.43, 95% CI = 1.10-1.85, P<0.01); primary syphilis was positively associated with serological cure, compared with participants with latent early syphilis (HR = 1.72, 95% CI = 1.27-2.33, P<0.001).
Two years after treatment, a higher percentage of early syphilis patients achieved serological cure. The study indicated that the syphilis stage and baseline serum titer were crucial factors associated with serological cure.
梅毒是一种全球范围内常见的传染病。血清学监测对于梅毒的管理非常重要。我们目前对这种血清学阴性反应的特征知之甚少。本研究旨在探讨早期梅毒治疗后血清学治愈的相关因素。
本研究采用回顾性队列研究，收集了 2011 年至 2019 年在深圳一家诊所就诊的早期梅毒患者的数据。采用单变量和多变量 Cox 比例风险回归模型，来确定治疗后 2 年早期梅毒患者的血清学治愈状态相关的因素。
共有 346 例（85.9%）梅毒患者达到了血清学治愈。多变量分析结果表明，与基线 TRUST 滴度≤1:8 相比，基线 TRUST 滴度>1:8 与血清学治愈的可能性增加相关（HR=1.43，95%CI=1.10-1.85，P<0.01）；与潜伏性早期梅毒相比，原发性梅毒与血清学治愈呈正相关（HR=1.72，95%CI=1.27-2.33，P<0.001）。
治疗后 2 年，早期梅毒患者中有更高比例达到了血清学治愈。研究表明，梅毒分期和基线血清滴度是与血清学治愈相关的关键因素。
