Chen Zhujun, Liu Tingting, Guo Haiqin, Zhou Yan, Duan Hailing, Zhu Bingjing, Chen Yongfeng, Gong Liang
Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Army Medical University Chongqing China.
Respirol Case Rep. 2025 Apr 7;13(4):e70143. doi: 10.1002/rcr2.70143. eCollection 2025 Apr.
Actinomycosis and mucormycosis are rare infections, and their coexistence in a single host is extremely uncommon. Actinomycosis of the trachea is a chronic septic condition caused by actinomycete infection, often misdiagnosed due to the difficulty of obtaining microbiological evidence. Mucormycosis, an invasive fungal infection, is characterised by rapid progression and high mortality, commonly occurring in immunocompromised patients. A 58-year-old woman with poorly controlled diabetes presented with a whitish mass in the main bronchus, identified via bronchoscopy. Pathological biopsy confirmed actinomycosis with mucormycosis. After treatment with cryotherapy, Holmium Laser, amphotericin B, and penicillin, she was successfully discharged. When imaging suggests intratracheal lesions, early bronchoscopy and etiological investigation are crucial to avoid misdiagnosis.
放线菌病和毛霉病是罕见的感染，它们在单一宿主中共存极为罕见。气管放线菌病是由放线菌感染引起的慢性化脓性疾病，由于难以获得微生物学证据，常被误诊。毛霉病是一种侵袭性真菌感染，其特点是进展迅速、死亡率高，常见于免疫功能低下的患者。一名58岁糖尿病控制不佳的女性，经支气管镜检查发现主支气管有白色肿物。病理活检证实为放线菌病合并毛霉病。经过冷冻治疗、钬激光治疗、两性霉素B和青霉素治疗后，她成功出院。当影像学提示气管内病变时，早期支气管镜检查和病因调查对于避免误诊至关重要。
