Kavoussi Shahryar K, Chen Shu-Hung, Farzaneh Negar, Farahi Arya, Mehrabani-Farsi Romtin, Aston Kenneth I, Chen Justin, Kavoussi Parviz K
Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, Texas.
Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
F S Rep. 2024 Dec 15;6(1):47-51. doi: 10.1016/j.xfre.2024.12.001. eCollection 2025 Mar.
To determine whether follicle size at midcycle transvaginal sonography imaging before luteal progesterone supplementation predicts modified natural cycle single frozen embryo transfer (mNC-SFET) outcomes.
Retrospective chart review.
Frozen embryo transfer charts were reviewed. After inclusion and exclusion criteria were applied, data were abstracted from cases of mNC-SFET (n = 115).
For group A, lead follicle measuring <16 mm on day of trigger or peak +ovulation predictor kit (n = 50), and for group B, lead follicle measuring ≥16 mm on day of trigger or peak +ovulation predictor kit (n = 65).
Follicle size analyzed as possible predictor of primary outcome ongoing pregnancy rate (OPR) as well as secondary outcomes implantation rate (IR), clinical pregnancy rate (CPR), and spontaneous abortion (SAB) rate via bivariate associations and multivariate logistic regression analyses.
Bivariate analyses showed no differences between groups in OPR (A, 48.0%, 24/50, and B, 44.6 %, 29/65), IR (A, 64.0%, 32/50, and B, 61.5%, 40/65), CPR (A, 58.0%, 29/50, and B, 52.3%, 34/65), and SAB rates (A, 25.0%, 8/32, and B, 27.5%, 11/40). Multivariate analysis to investigate potential confounding between lead follicle size and outcomes of interest showed no difference in the primary and secondary outcomes. Furthermore, multivariate analyses using lead follicle size as a continuous variable showed no difference in outcomes.
In normo-ovulatory women undergoing mNC-SFET with natural endometrial preparation with human chorionic gonadotropin trigger or luteinizing hormone surge to time frozen embryo transfer, lead follicle size before luteal phase supplementation does not impact clinical outcomes such as IR, CPR, SAB rate, or OPR.
确定在黄体期补充孕酮前的月经周期中期经阴道超声检查时的卵泡大小是否能预测改良自然周期单冻胚移植（mNC-SFET）的结局。
回顾性病历审查。
对冻胚移植病历进行审查。应用纳入和排除标准后，从mNC-SFET病例（n = 115）中提取数据。
A组为扳机日或峰值+排卵预测试剂盒检测时主导卵泡直径<16 mm（n = 50），B组为扳机日或峰值+排卵预测试剂盒检测时主导卵泡直径≥16 mm（n = 65）。
通过双变量关联分析和多因素逻辑回归分析，将卵泡大小作为主要结局指标持续妊娠率（OPR）以及次要结局指标着床率（IR）、临床妊娠率（CPR）和自然流产（SAB）率的可能预测因素进行分析。
双变量分析显示，两组在OPR（A组48.0%，24/50；B组44.6%，29/65）、IR（A组64.0%，32/50；B组61.5%，40/65）、CPR（A组58.0%，29/50；B组52.3%，34/65）和SAB率（A组25.0%，8/32；B组27.5%，11/40）方面无差异。调查主导卵泡大小与感兴趣结局之间潜在混杂因素的多因素分析显示，主要和次要结局均无差异。此外，将主导卵泡大小作为连续变量的多因素分析显示结局无差异。
在采用人绒毛膜促性腺激素扳机或黄体生成素峰进行自然内膜准备以确定冻胚移植时间的排卵正常女性中，黄体期补充孕酮前的主导卵泡大小不会影响IR、CPR、SAB率或OPR等临床结局。
