Agius Nicola', Ashton Catherine J, Willcock Helen, Magri David C
Department of Chemistry, Faculty of Science, University of Malta Msida MSD 2080 Malta
Department of Materials, Loughborough University Leicestershire LE11 3TU England UK.
RSC Adv. 2025 Apr 8;15(14):11121-11127. doi: 10.1039/d5ra01281c. eCollection 2025 Apr 4.
Four alkaloid-acrylamide water soluble copolymers with a mean hydrodynamic diameter of 3 nm were synthesised by free radical polymerization. The copolymers were characterised by H NMR, FTIR, GPC, DLS, UV-vis and fluorescence spectroscopy. A blue emission is observed with H switching of 185 and 175-fold for the quinidine and quinine copolymers, and 21 and 11-fold for the cinchonine and cinchonidine copolymers, while the presence of Cl, Br or I causes fluorescence quenching. In emission mode, the copolymers function as fluorescent H, X-driven INHIBIT logic gates (where X = Cl, Br or I). In absorbance mode, the copolymers function as colorimetric H, I-driven AND logic gates in 1 : 1 (v/v) THF/water with a 76-fold enhancement. The solution colour changes from colourless to yellow with formation of new absorbance bands at 288 nm and 353 nm due to a π-anion non-covalent charge transfer interaction. The copolymers may be useful as selective iodide sensors for medical and analytical diagnostics.
通过自由基聚合合成了四种平均流体力学直径为3 nm的生物碱-丙烯酰胺水溶性共聚物。通过核磁共振氢谱（H NMR）、傅里叶变换红外光谱（FTIR）、凝胶渗透色谱（GPC）、动态光散射（DLS）、紫外可见光谱和荧光光谱对共聚物进行了表征。奎尼丁和奎宁共聚物在H切换时观察到185倍和175倍的蓝色发射，辛可宁和辛可尼定共聚物则为21倍和11倍，而Cl、Br或I的存在会导致荧光猝灭。在发射模式下，共聚物用作荧光H、X驱动的抑制逻辑门（其中X = Cl、Br或I）。在吸光度模式下，共聚物在1:1（v/v）四氢呋喃/水中用作比色H、I驱动的与逻辑门，增强了76倍。由于π-阴离子非共价电荷转移相互作用，溶液颜色从无色变为黄色，并在288 nm和353 nm处形成新的吸收带。这些共聚物可用作医学和分析诊断中的选择性碘化物传感器。
