BACKGROUND: Thyroid disease continues to be one of the most prevalent disease groups worldwide, with its frequency and distribution being impacted by numerous factors. Significant progress has been achieved in recent years in thyroid nodules, largely due to the advent of novel detection and diagnostic techniques. This study aims to scrutinize the top 100 most frequently cited articles in thyroid nodule research, utilizing bibliometric analysis to identify trends, highlight critical focal points, and lay a groundwork for forthcoming investigations. METHODS: A comprehensive literature search was carried out using the SCI-E database, and all the recorded results were downloaded in plain text format for detailed analysis. The key terms analyzed with VOSviewer 1.6.18, CiteSpace 6.3r1, bibliometrix in R Studio (v.4.4.1), and Microsoft Excel 2021 software include country, institution, author, journal, and keywords. RESULTS: The publication timeframe extends from 1 January 2003 to 31 December 2021, reaching a peak citation count of 9,100. Notably, the United States leads in the number of published articles, with Harvard University standing out as a prestigious institution. These articles were featured in 45 diverse journals, with THYROID leading in publication volume. Nikiforov Yuri E. was the most prolific first author, appearing 10 times. Keyword analysis highlighted traditional research themes such as "fine needle aspiration," "carcinogens," and "management." However, "deep learning" has surfaced as a significant area of focus in recent studies. CONCLUSION: This study has extracted the bibliometric characteristics of the top 100 most-cited articles pertaining to TNs, providing an invaluable reference for upcoming studies. Through meticulous analysis, it has been determined that the primary research concentrations encompass the diagnosis of benign or malignant TNs, the management of TNs, and the subsequent monitoring of TNs, with deep learning emerging as a pivotal area of exploration.