格雷夫斯病的全球研究格局和新兴趋势：文献计量分析。

BACKGROUND: Graves' disease is a prevalent thyroid disorder and is the primary cause of hyperthyroidism. Significant progress has been made in understanding the epidemiology, pathogenesis, diagnosis, treatment, and prognosis of this disease. However, bibliometric analyses on Graves' disease are lacking. We aimed to comprehensively summarize the research, progression, and focal points of Graves' disease through data mining and integrated analysis of the existing literature. METHODS: We retrieved relevant literature on Graves' disease from 2003 to 2023 from the Web of Science database. We performed bibliometric analysis using CiteSpace and the R package Bibliometrix. RESULTS: We identified 10,901 publications from 132 countries, with a steady rise in the number of publications over the past 5 years. The US leads in publication volume, with the University of California System being the primary contributing institution. The journal Thyroid had the highest publication output, while the Journal of Clinical Endocrinology and Metabolism was the most frequently cited. These publications involved 2305 authors, with Antonelli Alessandro and Smith Terry being the most prolific. The most frequently cited articles were the "2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis" and the "Thyroid Association/European Group on Graves' orbitopathy guidelines for the management of Graves' orbitopathy." Analysis of the bursts of cited references, keywords, and their clustering revealed that research on Graves' disease predominantly centers on clinical management, thyroid-stimulating hormone receptors, thyroid hormones, autoimmunity and inflammation, Graves' ophthalmopathy, thyroid nodules, and thyroid cancer. CONCLUSION: This is the first comprehensive bibliometric study to summarize progress and trends in Graves' disease research. These results highlight recent research hotspots and promising directions, thereby providing a valuable reference for other scholars.

背景：Graves 病是一种常见的甲状腺疾病，也是导致甲状腺功能亢进的主要原因。人们对这种疾病的流行病学、发病机制、诊断、治疗和预后已经有了深入的了解。然而，关于 Graves 病的文献计量分析还很缺乏。我们旨在通过对现有文献的挖掘和综合分析，全面总结 Graves 病的研究进展和重点。

方法：我们从 Web of Science 数据库中检索了 2003 年至 2023 年与 Graves 病相关的文献，使用 CiteSpace 和 R 包 Bibliometrix 进行文献计量分析。

结果：我们从 132 个国家中确定了 10901 篇文献，过去 5 年来，出版物的数量稳步上升。美国在出版物数量上处于领先地位，加利福尼亚大学系统是主要的贡献机构。发表文献最多的期刊是 Thyroid，被引用最多的期刊是 Journal of Clinical Endocrinology and Metabolism。这些出版物涉及 2305 位作者，其中最有影响力的是 Antonelli Alessandro 和 Smith Terry。被引用最多的文章是“2016 年美国甲状腺协会关于甲状腺功能亢进和其他原因引起的甲状腺毒症的诊断和管理指南”和“甲状腺协会/欧洲 Graves 眼病小组关于 Graves 眼病管理的指南”。对被引文献、关键词的突现分析及其聚类分析表明，Graves 病的研究主要集中在临床管理、促甲状腺激素受体、甲状腺激素、自身免疫和炎症、Graves 眼病、甲状腺结节和甲状腺癌等方面。

结论：这是第一项全面的文献计量学研究，总结了 Graves 病研究的进展和趋势。这些结果突出了当前的研究热点和有前途的方向，为其他学者提供了有价值的参考。