Successful Treatment of Extensively Drug-Resistant Intracranial Infection with Meropenem and Cefoperazone Sodium Sulbactam: A Case Report.

BACKGROUND

intracranial infections, especially those caused by multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains, have posed an increasing challenge to treatment because of poor drug permeability through the blood-brain barrier (BBB) and increased bacterial drug resistance. Therefore, we aimed to explore a therapeutic schedule for intracranial infection.

CASE PRESENTATION

We reported a case of intracranial infection caused by XDR after severe traumatic brain injury, cerebrospinal fluid (CSF) rhinorrhea, and severe pneumonia that was successfully treated with meropenem and cefoperazone sodium sulbactam.

CONCLUSION

This case illustrated that meropenem combined with cefoperazone sodium sulbactam could still be a therapeutic option against intracranial XDR infection.