Ma Wenke, Zhang Chao, He Bei, Lv Xinwen, Luo Peng
Department of Neurosurgery, Baoji Central Hospital, Baoji, Shaanxi, People's Republic of China.
Department of Neurosurgery, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, People's Republic of China.
Infect Drug Resist. 2025 Apr 4;18:1721-1727. doi: 10.2147/IDR.S495491. eCollection 2025.
intracranial infections, especially those caused by multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains, have posed an increasing challenge to treatment because of poor drug permeability through the blood-brain barrier (BBB) and increased bacterial drug resistance. Therefore, we aimed to explore a therapeutic schedule for intracranial infection.
We reported a case of intracranial infection caused by XDR after severe traumatic brain injury, cerebrospinal fluid (CSF) rhinorrhea, and severe pneumonia that was successfully treated with meropenem and cefoperazone sodium sulbactam.
This case illustrated that meropenem combined with cefoperazone sodium sulbactam could still be a therapeutic option against intracranial XDR infection.
颅内感染，尤其是由多重耐药（MDR）或广泛耐药（XDR）菌株引起的感染，由于药物透过血脑屏障（BBB）的通透性差以及细菌耐药性增加，对治疗构成了越来越大的挑战。因此，我们旨在探索一种颅内感染的治疗方案。
我们报告了1例在严重创伤性脑损伤、脑脊液鼻漏和严重肺炎后由XDR引起的颅内感染病例，该病例经美罗培南和头孢哌酮钠舒巴坦成功治疗。
该病例表明，美罗培南联合头孢哌酮钠舒巴坦仍可能是治疗颅内XDR感染的一种选择。
