Tagami H
J Invest Dermatol. 1985 Aug;85(2):153-5. doi: 10.1111/1523-1747.ep12276580.
To elucidate the mechanisms underlying the self-healing process of experimental dermatophytosis produced in guinea pigs by an occlusive method with Trichophyton mentagrophytes, epidermal proliferative activity was evaluated by the in vivo tritiated thymidine-labeling technique performed at various intervals after the first and second infections. Determination of labeling indices disclosed that an increased epidermal proliferation correlated well with the severity of inflammatory changes, i.e., a peak activity was noted after 10 days in primary infection and at 2 days in reinfection, respectively, and was followed by subsequent spontaneous lesion clearance after 10 days. Application of a heat-killed spore suspension produced inflammatory changes with enhanced epidermopoiesis, similar to those induced by reinoculation of living spores, only in immune animals. The present results indicate that the dermatitic changes occurring in experimental dermatophytosis increase epidermopoiesis which facilitates elimination of the fungus from the stratum corneum and that host immune activity, particularly contact sensitivity to fungal antigen, exerts a crucial role to induce these changes.
为阐明用须癣毛癣菌闭塞法在豚鼠身上诱发的实验性皮肤癣菌病自愈过程的潜在机制，通过在初次和二次感染后的不同时间间隔进行体内氚标记胸腺嘧啶核苷标记技术，评估表皮增殖活性。标记指数的测定表明，表皮增殖增加与炎症变化的严重程度密切相关，即初次感染后10天和再次感染后2天分别出现峰值活性，随后在10天后病变自发清除。仅在免疫动物中，应用热灭活孢子悬液会产生炎症变化并增强表皮生成，类似于活孢子再次接种所诱导的变化。目前的结果表明，实验性皮肤癣菌病中发生的皮肤炎症变化会增加表皮生成，这有助于从角质层清除真菌，并且宿主免疫活性，特别是对真菌抗原的接触敏感性，在诱导这些变化中起关键作用。
