Guo Qian-Qian, Zhao Luxin, Zhu Wei
Department of Ophthalmology, Zibo Central Hospital, Zibo, Shandong, People's Republic of China.
Clin Optom (Auckl). 2025 Apr 4;17:133-138. doi: 10.2147/OPTO.S508943. eCollection 2025.
Diabetic macular edema (DME) is a vision-threatening complication of diabetic retinopathy. Intravitreal anti-VEGF injections offer effective treatment, but they carry a risk of corneal epithelial detachment, particularly in patients who have recently undergone cataract surgery.
A 63-year-old male developed bilateral DME following cataract surgery with intraocular lens implantation. His best-corrected visual acuity (BCVA) was 0.15 in the right eye and 0.5 in the left eye. The patient underwent bilateral intravitreal injections of the anti-VEGF agent conbercept. During preparation for the injection in the left eye, corneal epithelial bleb formation was observed. The patient received corneal patching therapy, with complete epithelial healing observed by day 10 post-injection. This case underscores the need for vigilant corneal monitoring during and after intravitreal injections in diabetic patients with prior cataract surgery.
Close observation of corneal epithelial healing is crucial in diabetic patients receiving intravitreal injections, especially those with a recent history of cataract surgery. Careful pre-injection assessment and vigilant post-injection management are essential to mitigate this potential complication.
糖尿病性黄斑水肿（DME）是糖尿病视网膜病变的一种威胁视力的并发症。玻璃体内注射抗血管内皮生长因子（VEGF）药物可提供有效的治疗，但存在角膜上皮脱离的风险，尤其是在近期接受过白内障手术的患者中。
一名63岁男性在白内障手术联合人工晶状体植入术后发生双侧DME。他的右眼最佳矫正视力（BCVA）为0.15，左眼为0.5。该患者接受了双侧玻璃体内注射抗VEGF药物康柏西普。在准备左眼注射时，观察到角膜上皮泡形成。患者接受了角膜贴片治疗，注射后第10天观察到上皮完全愈合。该病例强调了在有白内障手术史的糖尿病患者进行玻璃体内注射期间及之后进行密切角膜监测的必要性。
对于接受玻璃体内注射的糖尿病患者，尤其是近期有白内障手术史的患者，密切观察角膜上皮愈合情况至关重要。仔细的注射前评估和注射后密切管理对于减轻这种潜在并发症至关重要。
