Shen Jimmy, Dotel Ravindra, Colaco Clinton M G
The University of Sydney, Westmead Clinical School, Sydney, Australia.
Department of Infectious Diseases, Blacktown Hospital, Sydney, Australia.
IJID Reg. 2025 Feb 26;15:100610. doi: 10.1016/j.ijregi.2025.100610. eCollection 2025 Jun.
This study aimed to describe the epidemiology, clinical manifestations, management, and outcomes of group B streptococcus (GBS) bacteraemia in a large cohort spanning 13 years.
This retrospective study included patients aged 16 years or older with positive GBS blood cultures obtained from four metropolitan hospitals in Western Sydney, Australia, from 1 January 2011 to 31 December 2023, inclusive. The case details of these positive cultures were reviewed using electronic medical records.
A total of 344 patients with GBS bacteraemia were included during the 13-year study period. The median age was 65 years, and 50% of the patients were aged 65 years or older. Known risk factors were identified in 83.1% of the patients with cardiac disease, and diabetes mellitus was the most prevalent. Skin and soft tissue infections were the most common primary manifestation (32.0%). Pregnancy-related infections represented a notable proportion of the cases (16.3%). The 7- and 30-day mortality rates were 2.3% and 5.2% respectively, with a higher mortality rate of 9.3% for those aged 65 years or older. Penicillins were the most common antibiotic class used to treat GBS bacteraemia and its resultant manifestations (66.1%).
GBS bacteraemia most commonly occurs in individuals aged ≥65 years or during pregnancy. While mortality rates are generally low, they are twice as high in those aged ≥65 years.
本研究旨在描述13年间一个大型队列中B族链球菌（GBS）菌血症的流行病学、临床表现、治疗及转归。
这项回顾性研究纳入了2011年1月1日至2023年12月31日期间（含首尾）从澳大利亚悉尼西部四家都市医院获取GBS血培养阳性的16岁及以上患者。使用电子病历对这些阳性培养结果的病例详情进行了回顾。
在13年的研究期间，共纳入了344例GBS菌血症患者。中位年龄为65岁，50%的患者年龄在65岁及以上。83.1%的患者存在已知风险因素，其中心脏病最为常见，其次是糖尿病。皮肤和软组织感染是最常见的主要表现（32.0%）。与妊娠相关的感染占相当比例（16.3%）。7天和30天死亡率分别为2.3%和5.2%，65岁及以上患者的死亡率更高，为9.3%。青霉素是治疗GBS菌血症及其所致表现最常用的抗生素类别（66.1%）。
GBS菌血症最常见于65岁及以上人群或妊娠期间。虽然死亡率总体较低，但65岁及以上人群的死亡率是其两倍。
